Shimada H, Imanaka K, Hashimura T, Hirota S, Yonezawa K, Soezima T, Izumiyama K, Kono M, Goji K, Hamami M
Department of Urology, Kobe University School of Medicine.
Nihon Gan Chiryo Gakkai Shi. 1990 Jul 20;25(7):1385-90.
From May 1982 to Nov. 1987, 33 patients with bladder carcinoma were treated with preoperative radiotherapy (20 Gy/5fr) and total cystectomy. The over all 3-year survival rate was 70%. For T1 and T2, 3-year survival rate was 100%, but only 55% and 0% for T3 and T4 respectively. In 23 out of 33 patients, preoperative T-stage was confirmed by TUR-BT. Down-Staging was recognized in 7 out of 23 patients (30%). They were 0 out of 1 patients for Tcis (0%), 2 of 3 for T1 (67%), 3 of 6 for T2 (50%), 2 of 11 for T3 (18%) and 0 of 2 for T4 (0%). This protocol of preoperative radiotherapy is thought to be favorable for T1 and T2 bladder carcinoma, but inadequate for T3 and T4 tumors. Consequently, it is considered that higher dose radiotherapy and postoperative chemotherapy are necessary for T3 and T4 bladder carcinoma.
1982年5月至1987年11月，33例膀胱癌患者接受了术前放疗（20 Gy/5次分割）及全膀胱切除术。3年总生存率为70%。T1和T2期患者的3年生存率为100%，而T3和T4期患者的3年生存率分别仅为55%和0%。33例患者中有23例术前T分期经经尿道膀胱肿瘤电切术（TUR-BT）得以确认。23例患者中有7例（30%）出现降期。Tis期1例患者中降期为0例（0%），T1期3例患者中有2例（67%），T2期6例患者中有3例（50%），T3期11例患者中有2例（18%），T4期2例患者中降期为0例（0%）。术前放疗方案被认为对T1和T2期膀胱癌有利，但对T3和T4期肿瘤则不足。因此，对于T3和T4期膀胱癌，认为需要更高剂量的放疗及术后化疗。
