1990 - 2003年美国军人睾丸生殖细胞肿瘤的发病趋势
Trends in testicular germ cell tumors among U.S. military servicemen, 1990-2003.
作者信息
Enewold Lindsey, Zhou Jing, Devesa Susan S, Erickson Ralph L, Zhu Kangmin, McGlynn Katherine A
机构信息
United States Military Cancer Institute, Walter Reed Army Medical Center, 6900 Georgia Avenue NW, Building 1, Suite A109, Washington, DC 20307, USA.
出版信息
Mil Med. 2011 Oct;176(10):1184-7. doi: 10.7205/milmed-d-10-00476.
OBJECTIVE
To determine the incidence of testicular germ cell tumors among active duty males and compare it with the incidence in the general U.S. population.
METHODS
The Automated Cancer Tumor Registry and the Surveillance, Epidemiology, and End Results Program data from 1990 to 2003 were analyzed for men aged between 20 and 59 years by histology and stage at diagnosis. Rates were age adjusted using the male active duty military population as the standard.
RESULTS
Nonseminoma incidence was significantly lower in the military than in the general population (incidence rate ratio = 0.90, 95% confidence interval = 0.82-0.98). Trends in incidence tended to be similar in both the populations. Increases were observed for both histologic types but were only significant for seminoma (Automated Cancer Tumor Registry: 21% and Surveillance, Epidemiology, and End Results program: 16%; p < 0.05). Increases in incidence were only observed for localized tumors of both histologic types.
CONCLUSIONS
The lower incidence of nonseminoma in the military and the increased incidence of localized tumors in both populations remain unexplained.
目的
确定现役男性睾丸生殖细胞肿瘤的发病率，并将其与美国普通人群的发病率进行比较。
方法
分析1990年至2003年自动癌症肿瘤登记处以及监测、流行病学和最终结果计划的数据，这些数据来自年龄在20至59岁之间的男性，按诊断时的组织学和分期进行分析。发病率以男性现役军人人口为标准进行年龄调整。
结果
军队中非精原细胞瘤的发病率显著低于普通人群（发病率比值=0.90，95%置信区间=0.82-0.98）。两种人群的发病率趋势往往相似。两种组织学类型的发病率均有所上升，但仅精原细胞瘤的上升具有显著性（自动癌症肿瘤登记处：21%，监测、流行病学和最终结果计划：16%；p<0.05）。仅在两种组织学类型的局限性肿瘤中观察到发病率上升。
结论
军队中非精原细胞瘤发病率较低以及两种人群中局限性肿瘤发病率上升的原因仍无法解释。
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