Addiction Psychiatry Program, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Ann N Y Acad Sci. 2012 Feb;1248:89-106. doi: 10.1111/j.1749-6632.2011.06261.x. Epub 2011 Nov 30.
There is converging evidence that certain subpopulations of smokers, such as smokers with a serious mental illness like schizophrenia (SCZ), are more likely to become addicted to tobacco and are less likely to quit smoking. This review focuses on the unique risk factors that may increase vulnerability to the initiation and maintenance of nicotine addiction in persons with schizophrenia and other psychotic disorders and also reviews the latest approaches to treating nicotine addiction and schizophrenia based on our neurobiological understanding of central nicotinic receptor systems and related neurotransmitters. In addition, suggestions for future lines of research to better understand reasons for the comorbidity of nicotine addiction in schizophrenia are discussed.
越来越多的证据表明，某些吸烟人群，如患有精神分裂症等严重精神疾病的吸烟者，更容易上瘾，也更难戒烟。本综述重点介绍了可能增加精神分裂症和其他精神病患者易患尼古丁成瘾的独特风险因素，并根据我们对中枢烟碱受体系统和相关神经递质的神经生物学认识，综述了治疗尼古丁成瘾和精神分裂症的最新方法。此外，还讨论了为更好地了解精神分裂症中尼古丁成瘾的共病原因而进行未来研究的建议。
