Royal Adelaide Hospital, Adelaide, SA, Australia.
Crit Care Resusc. 2011 Dec;13(4):226-31.
To determine functional outcomes 6 months after intensive care unit admission for severe infection due to pandemic (H1N1) 2009 influenza and examine the relationship between nutrition during ICU admission and outcome.
DESIGN, SETTING AND PARTICIPANTS: Retrospective cohort study of patients with confirmed H1N1 influenza admitted to the ICU, Royal Adelaide Hospital, South Australia, June- October 2009.
Data were collected from medical records, dietitian notes and the daily ICU chart and included: demographics, daily kilocalories (Kcal) and protein delivered compared with dietitian-calculated requirement, ICU and hospital length of stay. Weight change and functional outcome at 6 months were determined prospectively by telephone interview using the 12-Item Short Form Health Survey and the EuroQol Group 5-Dimension Questionnaire.
Of 25 patients with H1N1 infection, 23 were included in the study (14 men; median age, 48 years (interquartile range [IQR], 39-55 years); median Acute Physiology and Chronic Health Evaluation (APACHE) II score, 17 (IQR, 13-21); median ICU length of stay, 9 days (IQR, 4-15 days); median hospital length of stay, 20 days (IQR, 11-30 days); ICU mortality, 3 (13%; 95% CI, 4%- 33%). Enteral feeding was commenced in 16 patients, who received a mean of 71% (SD, 27%; 95% CI, 57%-86%) of their energy and 62% (SD, 25%; 95% CI, 49%-75%) of their protein goals over their ICU stay. A more negative protein balance was associated with prolonged ICU stay (r = - 0.746; P = 0.003). Reduced success of feeding was associated with increased severity of illness and shorter ICU length of stay. Patients reported a good functional outcome at 6 months.
Patients admitted to this ICU with H1N1 infection were fed successfully during their stay. Critically ill patients surviving H1N1 infection had good functional outcomes at 6 months.
确定因 2009 年甲型 H1N1 流感大流行而导致严重感染入住重症监护病房 6 个月后的功能结果，并检查入住重症监护病房期间的营养与结果之间的关系。
设计、地点和参与者：2009 年 6 月至 10 月，在澳大利亚南澳大利亚州阿德莱德皇家医院对确诊为 H1N1 流感的入住重症监护病房的患者进行回顾性队列研究。
数据来自病历、营养师记录和重症监护病房日常图表，包括：人口统计学资料、每天提供的热量（千卡）和蛋白质与营养师计算的需求相比，重症监护病房和医院的住院时间。通过电话采访，前瞻性地使用 12 项简短健康调查和欧洲五维健康量表问卷，在 6 个月时确定体重变化和功能结果。
25 例甲型 H1N1 感染患者中，23 例纳入研究（14 例男性；中位年龄 48 岁（四分位间距 [IQR]，39-55 岁）；中位急性生理学和慢性健康评估（APACHE）Ⅱ评分 17（IQR，13-21）；中位重症监护病房住院时间 9 天（IQR，4-15 天）；中位住院时间 20 天（IQR，11-30 天）；重症监护病房死亡率 3 例（13%；95%可信区间，4%-33%）。16 例患者开始肠内喂养，他们在重症监护病房期间平均接受 71%（SD，27%；95%可信区间，57%-86%）的能量和 62%（SD，25%；95%可信区间，49%-75%）的蛋白质目标。负蛋白平衡与重症监护病房住院时间延长相关（r = - 0.746；P = 0.003）。喂养成功率降低与疾病严重程度增加和重症监护病房住院时间缩短相关。患者在 6 个月时报告功能结果良好。
入住该重症监护病房的甲型 H1N1 感染患者在住院期间得到了成功喂养。幸存的甲型 H1N1 感染重症患者在 6 个月时具有良好的功能结果。
