Section of Pulmonary, Critical Care, Sleep and Allergy, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Clin Pharmacol Ther. 2012 Jan;91(1):134-42. doi: 10.1038/clpt.2011.266. Epub 2011 Nov 30.
Phosphodiesterases (PDEs) are important modulators of inflammation and wound healing. In this capacity, specific targeting of PDEs for the treatment of many diseases, including chronic obstructive pulmonary disease (COPD), has been investigated. Currently, treatment of COPD is suboptimal. PDE4 modulates the inflammatory response of the lung, and inhibition of PDE4 may be a novel, COPD-specific approach toward more effective treatment strategies. This review describes the state of PDE4-inhibitor therapy for use in COPD treatment.
磷酸二酯酶（PDEs）是炎症和伤口愈合的重要调节剂。在这种作用下，针对 PDEs 的特定靶向治疗已被用于许多疾病的治疗，包括慢性阻塞性肺疾病（COPD）。目前，COPD 的治疗效果并不理想。PDE4 调节肺部的炎症反应，抑制 PDE4 可能是一种针对 COPD 的新型、特异性的更有效的治疗策略。本文综述了 PDE4 抑制剂治疗 COPD 的研究进展。
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