特发性震颤患者的睡眠：与正常对照和帕金森病患者的比较。
Sleep in essential tremor: a comparison with normal controls and Parkinson's disease patients.
机构信息
GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
出版信息
Parkinsonism Relat Disord. 2012 Mar;18(3):279-84. doi: 10.1016/j.parkreldis.2011.11.004. Epub 2011 Nov 30.
BACKGROUND
Recent studies have shed light on non-motor features of ET, such as depressive symptoms and cognitive changes, which might be attributed to pathophysiological changes in the brains of ET patients. Given these brain changes, we explored sleep abnormalities in ET patients.
METHODS
Sleep was assessed using the Epworth Sleepiness Scale (ESS) and the Pittsburgh Sleep Quality Index (PSQI) in 120 ET cases, 120 normal controls, and 40 PD cases.
RESULTS
The mean±SD (median) ESS score increased from normal controls (5.7±3.7 (5.0)), to ET cases (6.8±4.6 (6.0)), to PD cases (7.8±4.9 (7.0)), test for trend p=0.03. An ESS score >10 (an indicator of greater than normal levels of daytime sleepiness) was observed in 11 (9.2%) normal controls, compared to 27 (22.5%) ET cases and 10 (25.0%) PD cases (p=0.008 when comparing all three groups, and p=0.005 when comparing ET to normal controls). The global PSQI score was 7.8±2.8 (7.5) in controls, 8.0±3.3 (8.0) in ET cases, and 9.9±3.9 (10.0) in PD cases. The ET case-control difference was not significant (p=0.8), yet in a test for trend, PD cases had the highest PSQI score (most daytime sleepiness), followed by ET (intermediate), and lowest scores in controls (p=0.02).
CONCLUSIONS
Some sleep scores in ET were intermediate between those of PD cases and normal controls, suggesting that a mild form of sleep dysregulation could be present in ET.
背景
最近的研究揭示了 ET 的非运动特征，例如抑郁症状和认知变化，这些可能归因于 ET 患者大脑的病理生理变化。鉴于这些大脑变化，我们探讨了 ET 患者的睡眠异常。
方法
使用 Epworth 嗜睡量表（ESS）和匹兹堡睡眠质量指数（PSQI）对 120 例 ET 病例、120 例正常对照和 40 例 PD 病例进行睡眠评估。
结果
ESS 评分的平均值±标准差（中位数）从正常对照组（5.7±3.7（5.0））逐渐升高至 ET 组（6.8±4.6（6.0））和 PD 组（7.8±4.9（7.0）），趋势检验 p=0.03。在正常对照组中，有 11 例（9.2%）出现 ESS 评分>10（表示白天嗜睡程度高于正常水平），而在 ET 组中为 27 例（22.5%），在 PD 组中为 10 例（25.0%）（比较三组时 p=0.008，比较 ET 与正常对照组时 p=0.005）。对照组的 PSQI 总分为 7.8±2.8（7.5），ET 组为 8.0±3.3（8.0），PD 组为 9.9±3.9（10.0）。ET 病例对照差异无统计学意义（p=0.8），但趋势检验显示 PD 组 PSQI 评分最高（日间嗜睡最严重），其次是 ET 组（中度），对照组评分最低（p=0.02）。
结论
ET 中的一些睡眠评分在 PD 病例和正常对照组之间处于中间水平，这表明 ET 中可能存在轻度的睡眠失调。
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