Molyneux R J, Tropea J E, Elbein A D
Western Regional Research Center, USDA, Albany, California 94710.
J Nat Prod. 1990 May-Jun;53(3):609-14. doi: 10.1021/np50069a011.
A new indolizidine alkaloid has been isolated from the seeds of Castanospermum [1] australe and identified as 7-deoxy-6-epi-castanospermine by ms and 1H- and 13C-nmr spectroscopy. The alkaloid is the first trihydroxylated indolizidine to be isolated from this plant and may represent an intermediate in the biosynthetic pathway to the tetrahydroxy-indolizidines and -pyrrolizidines. It inhibits amyloglucosidase and yeast alpha-glucosidase but is significantly less active as a glycosidase inhibitor than its isomer swainsonine [2] and the tetrahydroxylated alkaloids castanospermine [3], 6-epi-castanospermine [4], and australine [5].
从澳洲栗豆树种子中分离出一种新的吲哚里西啶生物碱，通过质谱以及1H-和13C-核磁共振光谱鉴定为7-脱氧-6-表栗豆胺。该生物碱是首次从该植物中分离得到的三羟基化吲哚里西啶，可能是四羟基化吲哚里西啶和吡咯里西啶生物合成途径中的一个中间体。它能抑制淀粉葡萄糖苷酶和酵母α-葡萄糖苷酶，但作为糖苷酶抑制剂，其活性明显低于其异构体苦马豆素以及四羟基化生物碱栗豆胺、6-表栗豆胺和澳洲栗精胺。
