Lampl Y, Paniri Y, Eshel Y, Sarova-Pinhas I
Department of Neurology, Edith Wolfson Medical Center, Holon, Israel.
J Neurol Neurosurg Psychiatry. 1990 Aug;53(8):697-9. doi: 10.1136/jnnp.53.8.697.
This study examined the isoenzymatic pattern of LDH in the cerebrospinal fluid (CSF) as well as the ratio between the five fractions of LDH among patients with various brain tumours, carcinomatous meningitis and control groups. LDH 1/LDH 2 less than 1 was found significant for carcinomatous meningitis (p less than 0.001) and brain metastases (p less than 0.001). LDH 1/LDH 2 ratio was found to be significantly lower in carcinomatous meningitis than in brain metastases (p less than 0.05). No LDH 1/LDH 2 ratios smaller than 1 were found in the other groups. The LDH 1/LDH 2 ratio smaller than 1 was found in the early stage of carcinomatous meningitis without other evidences of the involvement of the leptomeninges. Examination of LDH 1/LDH 2 can be found as an adjunctive method to identify brain metastases and carcinomatous meningitis at the initial stage.
本研究检测了各种脑肿瘤、癌性脑膜炎患者及对照组脑脊液(CSF)中乳酸脱氢酶(LDH)的同工酶模式以及LDH五种组分之间的比例。发现癌性脑膜炎(p<0.001)和脑转移瘤(p<0.001)患者的LDH 1/LDH 2小于1具有显著意义。发现癌性脑膜炎患者的LDH 1/LDH 2比值显著低于脑转移瘤患者(p<0.05)。其他组未发现LDH 1/LDH 2比值小于1的情况。在癌性脑膜炎早期,在无软脑膜受累其他证据的情况下发现LDH 1/LDH 2比值小于1。检测LDH 1/LDH 2可作为在初始阶段识别脑转移瘤和癌性脑膜炎的辅助方法。