Department of Pathology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Leuk Lymphoma. 2012 Jun;53(6):1117-23. doi: 10.3109/10428194.2011.645209. Epub 2012 Jan 3.
Seven cases of testicular extranodal natural killer (NK)/T-cell lymphoma, nasal type, are reported, with a literature review. Two patients had a testicular lesion as the initial presentation, four had a history of nasal NK/T-cell lymphoma and the remaining patient had concomitant involvement of an adrenal gland. All patients underwent orchiectomy followed by chemotherapy (CT) and/or radiotherapy (RT). Follow-up data showed that two patients with non-primary tumors died of disease within 6 and 11 months, respectively. Histologically, the tumor had a diffuse growth pattern largely replacing the interstitial tissues. Neoplastic cells showed prominent angiocentric and angioinvasive features with focal coagulative necrosis and apoptotic bodies. Immunohistochemically, all cases were positive for cytoplasmic CD3ε and CD56. Epstein-Barr virus infection was demonstrated in all cases. Testicular NK/T-cell lymphoma, whether primary or secondary, was generally very aggressive with a poor outcome despite multimodality therapy. Novel molecular therapeutic targets and more effective treatments are needed, especially for disseminated or recurrent cases.
报告了 7 例睾丸结外自然杀伤（NK）/T 细胞淋巴瘤，鼻型，并进行了文献复习。2 例患者以睾丸病变为首发表现，4 例有鼻 NK/T 细胞淋巴瘤病史，1 例患者同时累及肾上腺。所有患者均行睾丸切除术，随后行化疗（CT）和/或放疗（RT）。随访资料显示，2 例非原发性肿瘤患者分别在 6 个月和 11 个月内死于疾病。组织学上，肿瘤呈弥漫性生长模式，大部分取代了间质组织。肿瘤细胞表现出明显的血管中心性和血管侵袭性特征，伴有局灶性凝固性坏死和凋亡小体。免疫组化染色显示，所有病例均细胞质 CD3ε 和 CD56 阳性。所有病例均证实存在 EBV 感染。尽管采用了多模式治疗，无论是原发性还是继发性睾丸 NK/T 细胞淋巴瘤通常都具有很强的侵袭性，预后不良。需要寻找新的分子治疗靶点和更有效的治疗方法，特别是针对播散性或复发性病例。
