Boriboonhirunsarn Dittakarn, Lertbunnaphong Tripop, Suwanwanich Morakot
Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Obstet Gynaecol Res. 2012 Jan;38(1):247-52. doi: 10.1111/j.1447-0756.2011.01702.x. Epub 2011 Dec 5.
The aim of this study was to determine the correlation between cord blood and maternal serum magnesium levels among pre-eclamptic pregnant women treated with magnesium sulfate.
A total of 36 pregnant women, >28weeks' gestation, diagnosed with pre-eclampsia and treated with magnesium sulfate (MgSO(4) ), were enrolled. Maternal and umbilical cord blood samples were obtained immediately after delivery and sent for determination of magnesium and calcium levels.
Mean maternal age was 27.4±6.4years and mean gestational age was 38.1±1.8weeks. Most were diagnosed with pre-eclampsia (94.5%), others had HELLP syndrome. Mean total MgSO(4) the women received was 14.4±6.0g and mean duration of treatment was 5.1±3.3h. Mean maternal serum and cord blood magnesium levels were 2.2±0.4 and 1.8±0.3mmol/L, respectively. Maternal magnesium and calcium levels showed significant positive correlation with their levels in cord blood (P<0.001). Significant positive correlation was found between total dose as well as duration of MgSO4 and maternal and cord blood magnesium levels (P<0.001) but was inversely correlated with maternal and cord blood calcium levels.
Maternal serum magnesium and calcium levels were correlated with cord blood levels in pre-eclamptic pregnant women who received MgSO4 therapy.
本研究旨在确定接受硫酸镁治疗的子痫前期孕妇脐带血与母血清镁水平之间的相关性。
共纳入36例孕周>28周、诊断为子痫前期并接受硫酸镁（MgSO₄）治疗的孕妇。分娩后立即采集母血和脐带血样本，送去检测镁和钙水平。
孕妇平均年龄为27.4±6.4岁，平均孕周为38.1±1.8周。大多数患者诊断为子痫前期（94.5%），其他患者患有HELLP综合征。患者接受的硫酸镁平均总量为14.4±6.0g，平均治疗时长为5.1±3.3小时。母血清和脐带血镁水平平均值分别为2.2±0.4和1.8±0.3mmol/L。母血镁和钙水平与其脐带血中的水平呈显著正相关（P<0.001）。硫酸镁总量及治疗时长与母血和脐带血镁水平呈显著正相关（P<0.001），但与母血和脐带血钙水平呈负相关。
接受硫酸镁治疗的子痫前期孕妇，其母血清镁和钙水平与脐带血水平相关。
