IRCCS, Istituto delle Scienze Neurologiche, University of Bologna, Bologna, Italy.
Sleep Med. 2011 Dec;12 Suppl 2:S64-7. doi: 10.1016/j.sleep.2011.10.014.
Agrypnia excitata (AE) is a syndrome characterized by the inability to sleep associated with a generalized motor and autonomic over-activation. AE is caused by a thalamo-limbic system dysfunction and comprises three different conditions: Fatal Familial Insomnia (FFI), Delirium Tremens (DT), and Morvan Syndrome (MS). Oneiric Stupor episodes (OS) are the peculiar motor behaviour of AE. During OS patients perform simple automatic gestures mimicking daily-life activities. This paper is the first description of the different characteristics of OS in two patients with MS and another with FFI, emphasizing the specific clinical features that reliably differentiate OS from REM sleep behaviour disorders.
兴奋性失眠(Agrypnia excitata,AE)是一种以睡眠障碍伴全身运动和自主神经过度兴奋为特征的综合征。AE 是由丘脑-边缘系统功能障碍引起的,包括三种不同的情况:家族性致死性失眠症(FFI)、震颤谵妄(DT)和莫尔万综合征(MS)。梦境昏迷发作(Oneiric Stupor episodes,OS)是 AE 的特殊运动行为。在 OS 期间,患者会做出简单的自动动作,模仿日常生活活动。本文首次描述了 2 例 MS 和 1 例 FFI 患者 OS 的不同特征,强调了可靠地区分 OS 与 REM 睡眠行为障碍的特定临床特征。