Arvin A M, Pollard R B, Rasmussen L E, Rand K H, Merigan T C
IARC Sci Publ (1971). 1978(24 Pt 2):745-51.
Our studies of in vitro cellular immune responses to herpesviruses have shown that, before treatment, lymphoma patients have decreased transformation to varicella-zoster virus antigen compared to herpes simplex virus and cytomegalovirus antigens. Interferon production to varicella-zoster virus and cytomegalovirus antigens is also decreased. During the first six months of treatment, decreased lymphocyte transformation and interferon production to all herpesviral antigens was observed. Among patients in long-term remission, recovery from the suppression associated with treatment was noted except that interferon production to varicella-zoster virus antigen remained decreased.
我们对疱疹病毒的体外细胞免疫反应研究表明，在治疗前，与单纯疱疹病毒和巨细胞病毒抗原相比，淋巴瘤患者对水痘 - 带状疱疹病毒抗原的转化能力下降。对水痘 - 带状疱疹病毒和巨细胞病毒抗原的干扰素产生也减少。在治疗的前六个月，观察到对所有疱疹病毒抗原的淋巴细胞转化和干扰素产生均减少。在长期缓解的患者中，除了对水痘 - 带状疱疹病毒抗原的干扰素产生仍减少外，与治疗相关的抑制作用有所恢复。
