Chua G T, Chan Y C, Cheng S W
Division of Vascular Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam, Hong Kong.
Vasc Health Risk Manag. 2011;7:671-5. doi: 10.2147/VHRM.S24876. Epub 2011 Nov 15.
Vitamin D deficiency has recently been implicated as a contributory factor in the development of peripheral arterial disease (PAD).
A review of the published literature on PAD and vitamin D was undertaken using Medline, PubMed, and Embase, and cross-referenced. All relevant published papers on the subject were reviewed.
Published studies have shown that there is a significant association between vitamin D and PAD. Populations with lower vitamin D levels are more likely to develop PAD in a graded manner. Higher amputation rates are also observed among patients with PAD and lower vitamin D levels. In addition, vitamin D deficiency is significantly associated with increased risk of cardiovascular adverse events. This was also observed in the mouse model where low vitamin D led to the development of atherosclerosis.
This study shows that vitamin D deficiency could be an independent risk factor for the development of PAD and that this risk factor is easily correctable. Further studies should look into the effects of vitamin D supplementation in patients with PAD.
维生素D缺乏最近被认为是外周动脉疾病（PAD）发生的一个促成因素。
使用Medline、PubMed和Embase对已发表的关于PAD和维生素D的文献进行综述，并相互参照。对该主题所有相关的已发表论文进行了审查。
已发表的研究表明维生素D与PAD之间存在显著关联。维生素D水平较低的人群更有可能以分级方式患上PAD。在PAD患者且维生素D水平较低的人群中也观察到较高的截肢率。此外，维生素D缺乏与心血管不良事件风险增加显著相关。在小鼠模型中也观察到了这一点，低维生素D导致动脉粥样硬化的发生。
本研究表明维生素D缺乏可能是PAD发生的一个独立危险因素，并且这个危险因素易于纠正。进一步的研究应探讨补充维生素D对PAD患者的影响。
