Bonatto Simone, Paniz Vera Maria Vieira, Dutra Clandio de Freitas, Henn Ruth Liane
. Área do Conhecimento de Ciências da Vida: Universidade de Caxias do Sul, Caxias do Sul, RS, Brasil.
. Programa de Pós-Graduação em Saúde Coletiva, Universidade do Vale do Rio dos Sinos, São Leopoldo, RS, Brasil.
Rev Assoc Med Bras (1992). 2020 Mar;66(3):268-274. doi: 10.1590/1806-9282.66.3.268.
To investigate the association between low serum vitamin D levels and peripheral arterial disease (PAD).
A cross-sectional study with a consecutive sample of 133 individuals from Caxias do Sul, Brasil. We considered PAD patients those with an ankle-brachial index (ABI) ≤ 0.90 or with arterial revascularization. Vitamin D serum level was categorized as sufficient (≥30 ng/mL), insufficient (>20 to 29 ng/mL), and deficient (<20 ng/mL). Prevalence ratios (RP) were calculated through Poisson regression.
The prevalence of PAD was 50.7% (95% CI 42-59). After adjustment for potential PAD risk factors, RP were 1.08 (95% CI 0.66-1.76) for insufficient serum level and 1.57 (95% CI 0.96-2.57) for deficient vitamin D serum level; (p for trend = 0.020).
Vitamin D serum levels showed an inverse and significant dose-response relationship with PAD.
探讨血清维生素D水平低与外周动脉疾病（PAD）之间的关联。
一项横断面研究，对来自巴西南卡希亚斯的133名个体进行连续抽样。我们将踝臂指数（ABI）≤0.90或接受动脉血运重建的患者视为PAD患者。血清维生素D水平分为充足（≥30 ng/mL）、不足（>20至29 ng/mL）和缺乏（<20 ng/mL）。通过泊松回归计算患病率比（RP）。
PAD的患病率为50.7%（95%可信区间42 - 59）。在对潜在的PAD危险因素进行调整后，血清水平不足时的RP为1.08（95%可信区间0.66 - 1.76），维生素D血清水平缺乏时的RP为1.57（95%可信区间0.96 - 2.57）；（趋势p值 = 0.020）。
血清维生素D水平与PAD呈负相关且存在显著的剂量反应关系。
