Fiorentino Lavinia, Rissling Michelle, Liu Lianqi, Ancoli-Israel Sonia
Drug Discov Today Dis Models. 2011 Winter;8(4):167-173. doi: 10.1016/j.ddmod.2011.05.001.
Breast cancer is the most commonly diagnosed cancer in women. Insomnia is a significant problem in breast cancer patients, affecting between 20% to 70% of newly diagnosed or recently treated cancer patients. Pain, fatigue, anxiety, and depression are also common conditions in breast cancer and often co-occur with insomnia in symptom clusters, exacerbating one another, and decreasing quality of life (QOL). There have been no clinical trials of drugs for sleep in cancer. Cognitive behavioral psychotherapies on the other hand, have shown some of the most positive results in alleviating the distressing symptoms that often accompany the breast cancer experience, but even these studies have not targeted the symptom cluster. Pharmacological as well as non-pharmacological treatments need to be explored. It might be that a combined pharmacological and behavioral treatment is most efficacious. In short, substantially more research is needed to fully understand and treat the symptom cluster of insomnia, fatigue, pain, depression and anxiety in breast cancer.
乳腺癌是女性中最常被诊断出的癌症。失眠是乳腺癌患者的一个重大问题，影响着20%至70%的新诊断或近期接受治疗的癌症患者。疼痛、疲劳、焦虑和抑郁也是乳腺癌患者的常见状况，且常常在症状群中与失眠共同出现，相互加剧，降低生活质量（QOL）。目前尚无针对癌症患者睡眠问题的药物临床试验。另一方面，认知行为心理疗法在缓解乳腺癌患者常伴随的痛苦症状方面显示出了一些最积极的效果，但即便这些研究也未针对症状群。需要探索药物治疗以及非药物治疗方法。或许药物治疗与行为治疗相结合最为有效。简而言之，需要进行更多的研究，以全面了解并治疗乳腺癌患者中失眠、疲劳、疼痛、抑郁和焦虑的症状群。
