持久性有机氯暴露与妊娠丢失：一项前瞻性队列研究。
Persistent Organochlorine Exposure and Pregnancy Loss: A Prospective Cohort Study.
作者信息
Pollack Anna Z, Buck Louis Germaine M, Lynch Courtney D, Kostyniak Paul J
机构信息
Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, USA.
出版信息
J Environ Prot (Irvine, Calif). 2011 Aug 1;2(6):683-691. doi: 10.4236/jep.2011.26079.
Polychlorinated biphenyls (PCBs) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) are suspected reproductive toxicants. We assessed serum concentration of 76 PCB congeners, DDE, and risk of human chorionic gonadotropin confirmed pregnancy loss among 79 women followed for up to 12 menstrual cycles or until pregnancy. 55 women had live births, 14 experienced pregnancy losses, and 10 did not achieve pregnancy. PCBs and DDE were quantified using gas chromatography with electron capture. PCBs were grouped a priori by biologic activity. Cox proportional hazard regression adjusting for age (categorized 24 - 29, 30 - 34) and average standardized alcohol and cigarette intake (continuous) was used to estimate hazard ratios (HR) of pregnancy loss. Estrogenic PCBs (HR = 1.66, 95% CI: 0.68, 4.02), anti-estrogenic PCBs (HR = 0.10, 95% CI: <0.01, 67.07) and DDE (HR = 1.43, 95% CI: 0.45, 4.52) were not statistically significantly associated with pregnancy loss. Our results provide some signal that estrogenic and antiestrogenic PCBs may be differentially associated with pregnancy loss. Further research is needed to elucidate these associations.
多氯联苯（PCBs）和1,1-二氯-2,2-双（对氯苯基）乙烯（DDE）被怀疑是生殖毒性物质。我们评估了79名女性血清中76种多氯联苯同系物、DDE的浓度，以及人绒毛膜促性腺激素确诊的妊娠丢失风险，这些女性随访了长达12个月经周期或直至怀孕。55名女性活产，14名经历了妊娠丢失，10名未怀孕。采用带电子捕获的气相色谱法定量多氯联苯和DDE。多氯联苯根据生物活性进行了先验分组。使用Cox比例风险回归对年龄（分为24 - 29岁、30 - 34岁）以及平均标准化酒精和香烟摄入量（连续变量）进行校正，以估计妊娠丢失的风险比（HR）。具有雌激素活性的多氯联苯（HR = 1.66，95%CI：0.68，4.02）、具有抗雌激素活性的多氯联苯（HR = 0.10，95%CI：<0.01，67.07）和DDE（HR = 1.43，95%CI：0.45，4.52）与妊娠丢失无统计学显著关联。我们的结果提供了一些迹象，表明具有雌激素活性和抗雌激素活性 的多氯联苯可能与妊娠丢失存在不同的关联。需要进一步的研究来阐明这些关联。
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