Inserm, CESP Center for Research in Epidemiology and Population Health, U 1018, Villejuif, France.
Environ Res. 2011 Aug;111(6):861-70. doi: 10.1016/j.envres.2011.06.001.
Dichlorodiphenyltrichloroethane (DDT) and polychlorinated biphenyls (PCBs) are persistent organochlorine compounds bioaccumulating in human tissues. Body burden of organochlorines may be influenced by individual characteristics such as age, weight variations, breastfeeding, dietary habits and place of residence.
To assess the current serum concentrations of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE), the main DDT breakdown product, and of PCBs in women from two French administrative areas (Ille-et-Vilaine and Côte d'Or). To identify determinants of the current serum levels among individual characteristics related to intake, metabolism, and excretion of organochlorines.
We measured serum p,p'-DDE and PCB levels in 1055 general population women who were recruited in 2005-2007 to serve as controls in a case-control study on breast cancer. Associations between organochlorine levels and age, current body mass index (BMI), BMI change during the last 10 years, dietary habits, breastfeeding history, residence area and education were assessed in multivariate analyses.
Median concentrations of p,p'-DDE and total PCBs were 85 and 240ng/g lipid, respectively. Based on multivariate analyses, the main predictors of high p,p'-DDE levels included age and frequent consumption of saltwater fish in women below 50 years, and high BMI in older women. Total PCB levels increased markedly with age. Among older women, other important predictors of high PCB levels included frequent consumption of saltwater fish and low BMI. Our results are also suggestive of an inverse association between PCB levels and BMI gain during the last ten years. Women in Côte d'Or had significantly higher PCB levels than women in Ille-et-Vilaine.
The patterns of associations between determinants and serum organochlorine concentrations suggest that human PCB contamination is still ongoing in France. The most important predictors of serum p,p'-DDE and PCB concentrations among French women include age, body mass index, dietary habits, and place of residence.
滴滴涕（DDT）和多氯联苯（PCBs）是持久性有机氯化合物，在人体组织中生物累积。有机氯化合物的体内负荷可能受个体特征的影响，如年龄、体重变化、母乳喂养、饮食习惯和居住地。
评估来自法国两个行政区域（Ille-et-Vilaine 和 Côte d'Or）的女性当前血清中 1,1-二氯-2,2-双（对氯苯基）乙烯（p,p'-DDE），即 DDT 的主要降解产物，以及 PCBs 的浓度。确定与有机氯摄入、代谢和排泄有关的个体特征与当前血清水平之间的关系。
我们在 2005-2007 年招募了 1055 名一般人群女性作为乳腺癌病例对照研究的对照组，测量了她们的血清 p,p'-DDE 和 PCB 水平。在多元分析中，评估了有机氯水平与年龄、当前体重指数（BMI）、过去 10 年 BMI 变化、饮食习惯、母乳喂养史、居住区域和教育之间的关系。
p,p'-DDE 和总 PCBs 的中位数浓度分别为 85 和 240ng/g 脂质。基于多元分析，高 p,p'-DDE 水平的主要预测因素包括年龄和 50 岁以下女性频繁食用咸水鱼，以及年龄较大的女性高 BMI。总 PCB 水平随年龄显著增加。在年龄较大的女性中，其他重要的高 PCB 水平预测因素包括频繁食用咸水鱼和低 BMI。我们的结果还表明，PCBs 水平与过去十年 BMI 增加之间存在反比关系。Côte d'Or 的女性 PCBs 水平明显高于 Ille-et-Vilaine 的女性。
决定因素与血清有机氯浓度之间的关联模式表明，法国的 PCBs 污染仍在继续。法国女性血清 p,p'-DDE 和 PCB 浓度的最重要预测因素包括年龄、体重指数、饮食习惯和居住地。
