Plowright W
IARC Sci Publ (1971). 1978(24 Pt 2):965-80.
An account is presented of the development and use of herpesvirus vaccines in domestic animals, with particular reference to those viruses causing cytolytic rather than oncogenic infections. The chief infections covered are Aujeszky's disease (AD or pseudorabies), infectious bovine rhinotracheitis (IBR) and equine rhinopneumonitis (equine abortion; EHV-1). Others mentioned are feline viral rhinotracheitis and malignant catarrhal fever of cattle. Both live-modified and inactivated vaccines are widely used or under development for ADV, IBR and EHV-1. Live vaccines are generally regarded as successful in some circumstances but have major drawbacks, both in regard to safety or immunogenicity for the individual animal or to efforts to control and eliminate the viruses from whole populations. Difficulties remian in the preparation and use of inactivated vaccines, which still suffer from many of the epidemiological objections raised against modified live vaccines.
本文介绍了家畜疱疹病毒疫苗的研发与应用，特别提及那些引起溶细胞性而非致癌性感染的病毒。所涵盖的主要感染疾病有奥耶斯基氏病（AD或伪狂犬病）、传染性牛鼻气管炎（IBR）和马鼻肺炎（马流产；EHV-1）。还提到的其他疾病有猫病毒性鼻气管炎和牛恶性卡他热。减毒活疫苗和灭活疫苗广泛用于ADV、IBR和EHV-1的预防，或正处于研发阶段。活疫苗在某些情况下通常被认为是成功的，但存在重大缺陷，无论是对个体动物的安全性或免疫原性，还是对从整个种群中控制和消除病毒的努力而言。灭活疫苗的制备和使用仍存在困难，它们仍然受到许多针对减毒活疫苗提出的流行病学方面的质疑。
