Kawatani T, Maeda N, Hosoda A, Agou H, Nakai K, Kawasaki H
2nd Department of Internal Medicine, Tottori University School of Medicine.
Rinsho Ketsueki. 1990 Jun;31(6):842-6.
A 76-year-old female was admitted to our hospital because of anemia. Complete blood count was as follows: RBC 2.37 X 10(6)/microliters, Hb 7.7 g/dl, WBC 2,600/microliters, Plt 105 X 10(3)/microliters. A bone marrow aspirate revealed 40.8% plasmacytoid cells showing the characteristics of plasma cells by electron microscopy. Total serum protein was 5.4 g/dl. Monoclonal protein was not observed by electrophoresis. On immunoelectrophoresis, M-bow was not observed in the serum or in 50-fold concentrated urine. The plasma cells were negative for cytoplasmic IgG, M, A, E, D, kappa or lambda by immunoperoxidase studies. Although radiologic studies of the bones did not reveal destructive or punched out lesions, we diagnosed this case as a nonproducing myeloma and the patient responded to MP therapy. This case was considered interesting as regards the pathological entity of myeloma.
一名76岁女性因贫血入住我院。全血细胞计数结果如下：红细胞（RBC）2.37×10⁶/微升，血红蛋白（Hb）7.7克/分升，白细胞（WBC）2600/微升，血小板（Plt）105×10³/微升。骨髓穿刺显示40.8%的浆细胞样细胞，通过电子显微镜观察具有浆细胞的特征。血清总蛋白为5.4克/分升。电泳未观察到单克隆蛋白。免疫电泳显示，血清或50倍浓缩尿液中均未观察到M带。免疫过氧化物酶研究显示，浆细胞的细胞质免疫球蛋白G、M、A、E、D、κ或λ均为阴性。尽管骨骼的放射学检查未发现破坏性或穿凿样病变，但我们将该病例诊断为非分泌型骨髓瘤，患者对MP疗法有反应。就骨髓瘤的病理实体而言，该病例被认为很有趣。
