Shimmyozu K, Kadokura N, Itoyama T, Tara M, Maruyama I, Osame M
Third Department of Internal Medicine, School of Medicine, Kagoshima University.
Rinsho Ketsueki. 1990 Jul;31(7):1036-7.
We investigated serum isoferritin patterns in 2 patients with reactive hemophagocytic histiocytosis (HH) and 1 patient with neoplastic HH (malignant histiocytosis) whose serum ferritin levels were extraordinarily high. Serum ferritins in 2 patients with reactive HH were composed of mildly (pI 5.55 to 5.10) to intermediately (pI 4.81 to 4.82) acidic isoferritins, while those in patient with neoplastic HH were composed of more acidic (pI 4.70 to 4.45) isoferritins. These results indicate that the main constituents of the increased serum ferritins in HH would be acidic isoferritins, and that more acidic isoferritins would be increased in neoplastic HH than reactive HH.
我们研究了2例反应性噬血细胞性组织细胞增生症（HH）患者和1例肿瘤性HH（恶性组织细胞增生症）患者的血清铁蛋白异构体模式，这3例患者的血清铁蛋白水平都异常高。2例反应性HH患者的血清铁蛋白由轻度酸性（等电点5.55至5.10）至中度酸性（等电点4.81至4.82）的异构体组成，而肿瘤性HH患者的血清铁蛋白由酸性更强（等电点4.70至4.45）的异构体组成。这些结果表明，HH患者血清铁蛋白升高的主要成分是酸性铁蛋白异构体，并且肿瘤性HH比反应性HH有更多酸性更强的铁蛋白异构体增加。
