Tsukada A, Furuya T
Department of Dermatology, Dokkyo University School of Medicine.
Nihon Hifuka Gakkai Zasshi. 1990 May;100(6):701-10.
Histological examination was performed on the oral mucosa of 25 patients with PSS which consisted of 16 cases of Acrosclerotic type (A type) and 9 cases of Diffuse type (D type). Results obtained were as follows: (A) Sclerotic change of connective tissue were found in the submucosal area (a type) and in the salivary peri-glandular++ area (b type) and also in the both areas (c type). (1) In A type of PSS, sclerotic changes was found in 14 out of 16 cases (87.5%) and (2) In D type, 9 out of 9 cases (100%). (3) In D type, sclerotic changes were marked and, moreover, found in the earlier stage of disease more than in A type. (B) Inflammatory change of salivary gland based on the criteria of Chisholm and Mason. (1) Moderate and marked salivary gland adenitis were found in 6 out of 16 cases of A type (37.5%) and 2 out of 9 cases of D type (22%). (2) Adenitis were found more frequently in the early stage of disease in both types. From above described findings, it is concluded that 1) as to sclerotic change, the early and marked changes were found in D type and 2) as to inflammation of salivary gland, no significant difference was found between both types.
对25例硬皮病患者的口腔黏膜进行了组织学检查，其中包括16例肢端硬化型（A型）和9例弥漫型（D型）。结果如下：（A）在黏膜下区域（a型）、唾液腺周围区域（b型）以及两个区域均发现结缔组织硬化改变（c型）。（1）在A型硬皮病中，16例中有14例（87.5%）出现硬化改变；（2）在D型中，9例中有9例（100%）出现硬化改变。（3）在D型中，硬化改变明显，而且在疾病早期比A型更易出现。（B）根据奇泽姆和梅森的标准对唾液腺进行炎症改变评估。（1）在A型的16例中有6例（37.5%）出现中度和重度唾液腺腺炎，在D型的9例中有2例（22%）出现。（2）两种类型在疾病早期腺炎的发生频率均更高。从上述结果可以得出结论：1）关于硬化改变，D型出现得更早且更明显；2）关于唾液腺炎症，两种类型之间未发现显著差异。
