College of Medical Sciences, Nova Southeastern University, Ft. Lauderdale, Florida, USA.
Skin Res Technol. 2012 Nov;18(4):504-10. doi: 10.1111/j.1600-0846.2011.00582.x. Epub 2011 Dec 5.
BACKGROUND/PURPOSE: Skin tissue dielectric constant (TDC) measurements at 300 MHz provide non-invasive data on free and bound tissue water. TDC-data is available for some body sites, but most is for female forearm. Contrastingly, there are no data on face-skin or comparative data between genders. Our goals were to obtain facial-TDC reference values and determine if TDC-values differ between genders.
TDC was measured at forehead, cheek, and forearm in 60 young adults (30 men) to a 1.5-mm depth. Measured TDC-values were compared with TDC-values calculated using skin-thickness data.
Measured TDC-values ranged from 39.6 ± 2.9 at male-forehead to 28.2 ± 2.4 at female forearm and were significantly different (P < 0.001) among each site in the order forehead > cheek >forearm. Male TDC-values were greater than female TDC-values (P < 0.01) with differences from 5.6% at forehead to 11.3% at forearm. Calculated TDC-values incorporating site and gender skin-thickness differences yielded TDC-values at the most 3% different from measured values.
Gender differences should be considered in clinical studies in which men and women are included in a common study population with respect to experimental design and data interpretation. This is especially true if absolute TDC-values are of interest rather than changes in TDC-values on the same subject subsequent secondary to an intervention.
背景/目的:300MHz 下的皮肤组织介电常数(TDC)测量可提供游离组织水和结合组织水的非侵入性数据。已有一些身体部位的 TDC 数据,但大多是女性前臂的。相比之下,面部皮肤的 TDC 数据却没有,不同性别之间也没有比较数据。我们的目标是获得面部皮肤 TDC 的参考值,并确定 TDC 值是否存在性别差异。
在 60 名年轻成年人(30 名男性)的前额、脸颊和前臂处测量了 1.5mm 深度的 TDC。将实测 TDC 值与使用皮肤厚度数据计算得到的 TDC 值进行比较。
实测 TDC 值范围从男性前额的 39.6 ± 2.9 到女性前臂的 28.2 ± 2.4,每个部位的 TDC 值均存在显著差异(P < 0.001),前额 > 脸颊 > 前臂。男性 TDC 值大于女性 TDC 值(P < 0.01),差异范围从 5.6%(前额)到 11.3%(前臂)。考虑到部位和性别皮肤厚度差异,计算得到的 TDC 值与实测值的差异最大不超过 3%。
在涉及男性和女性的临床研究中,应考虑性别差异,包括实验设计和数据解释。如果关注的是绝对 TDC 值,而不是同一对象后续干预后 TDC 值的变化,则尤其如此。