[关于触珠蛋白在内镜注射硬化治疗中的应用价值研究]

[Study on the usefulness of haptoglobin used on endoscopic injection sclerotherapy].

作者信息

Matsumoto A, Miyoshi H, Takada K, Hayashi K, Asada S, Hirata I, Ohshiba S

机构信息

Second Department of Internal Medicine, Osaka Medical College.

出版信息

Nihon Shokakibyo Gakkai Zasshi. 1990 Jun;87(6):1343-9.

PMID:2214258

Abstract

The effect of haptoglobin (Hp) used on endoscopic injection sclerotherapy (EIS) was evaluated by examining the increase of serum free hemoglobin (FHb) and the changes of renal function. In control group, the increase of serum FHb (delta FHb) was paralleled with the volume of 5% ethanolamine Oleate (EO) injected intravariceally, and free Hp (FHp) was disappered in this group soon after EIS. On the contrary, in the group treated with Hp, neither the increase of FHb nor decrease of FHp were recognized. The significant increase of urine beta 2 microglobulin and NAG was recognized in control group. Therefore, if Hp is used at initial EIS, it would be prevented that serum FHb due to intravascular hemolysis increases, consequently the possibility of renal dysfunction.

摘要

通过检测血清游离血红蛋白（FHb）的增加和肾功能的变化，评估了使用触珠蛋白（Hp）对内镜注射硬化疗法（EIS）的影响。在对照组中，血清FHb的增加（ΔFHb）与经静脉内注射的5%油酸乙醇胺（EO）的体积平行，并且在EIS后不久该组中的游离Hp（FHp）消失。相反，在使用Hp治疗的组中，未观察到FHb的增加或FHp的减少。在对照组中，尿β2微球蛋白和NAG显著增加。因此，如果在初次EIS时使用Hp，可以防止因血管内溶血导致的血清FHb增加，从而降低肾功能障碍的可能性。