苯巴比妥给药诱导大鼠肝脏中黄素腺嘌呤二核苷酸合成酶系统
Induction of the FAD synthetase system in rat liver by phenobarbital administration.
作者信息
Hamajima S, Ono S, Hirano H, Obara K
出版信息
Int J Vitam Nutr Res. 1979;49(1):59-63.
FMN and FAD synthesizing activities in rat liver were investigated when drug metabolizing enzymes were induced by phenobarbital. The FAD content of the liver mitochondrial and microsomal fractions were increased by either one shot administration or three successive daily administrations of phenobarbital. Similarly the flavokinase and FAD pyrophosphorylase activities also increased in the mitochondrial, microsomal and cytosol fractions. The authors have verified that activation of the FAD synthesizing system is induced by phenobarbital and suggest that the FMN and FAD contents are regulated not only by variations of flavin enzyme apoprotein, but also by changes in flavokinase and FAD pyrophosphorylase activities.
当用苯巴比妥诱导药物代谢酶时，研究了大鼠肝脏中FMN和FAD的合成活性。单次给药或连续三天每日给药苯巴比妥均可使肝脏线粒体和微粒体部分的FAD含量增加。同样，线粒体、微粒体和胞质溶胶部分的黄素激酶和FAD焦磷酸化酶活性也增加。作者已经证实苯巴比妥可诱导FAD合成系统的激活，并表明FMN和FAD的含量不仅受黄素酶脱辅基蛋白变化的调节，还受黄素激酶和FAD焦磷酸化酶活性变化的调节。
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