二肽衍生膦催化的丙二烯与马来酰亚胺的不对称[3+2]环加成反应：构建含有两个叔立体中心的官能化双环环戊烯的简便方法。
Asymmetric [3+2] annulation of allenes with maleimides catalyzed by dipeptide-derived phosphines: facile creation of functionalized bicyclic cyclopentenes containing two tertiary stereogenic centers.
机构信息
Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, 130 MeiLong Road, Shanghai 200237, PR China.
出版信息
Chem Commun (Camb). 2012 Jan 25;48(7):970-2. doi: 10.1039/c2cc16904e. Epub 2011 Dec 5.
PMID:22143407
Abstract
D-Threonine-L-tert-leucine-derived bifunctional phosphine, Cat. 11, catalyzed highly enantioselective [3+2] annulation of maleimides with allenes has been disclosed, allowing the synthesis of optically active functionalized bicyclic cyclopentenes containing two tertiary stereogenic centers in good to high yields along with good to high enantioselectivities.
摘要
D-苏氨酸-L-叔亮氨酸衍生的双功能膦配体 Cat. 11 已被揭示，可催化马来酰亚胺与丙二烯的高对映选择性[3+2]环加成反应，从而以良好至高的收率和良好至高的对映选择性合成含有两个叔立体中心的光学活性官能化双环环戊烯。
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