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[慢性肺部疾病中高血浆肾素活性病例报告及血管紧张素 II 类似物(1-肌氨酸,8-异亮氨酸-血管紧张素 II)的作用]

[A case report of high plasma renin activity in chronic pulmonary disease and the effect of angiotensin-II-analogue (1-sarcosine, 8-isoleucine-angiotensin-II)].

作者信息

Nakano T, Yamamoto T, Fujioka H, Maeda J, Iwahashi N, Tamura S, Hada T, Higashino K

机构信息

Third Department of Internal Medicine, Hyogo College of Medicine, Japan.

出版信息

Nihon Kyobu Shikkan Gakkai Zasshi. 1990 Apr;28(4):605-11.

PMID:2214403
Abstract

Five patients with chronic pulmonary diseases (3 pulmonary emphysema, 1 chronic respiratory failure caused by old tuberculosis, 1 diffuse panbronchiolitis) showed a marked increase of plasma angiotensin-I and PRA level, which was accompanied by an increase of angiotensin-II level, however, whose systemic blood pressure was not elevated. The intravenous infusion of angiotensin-II-analogue (1-Sarcosine, 8-Isoleucine-Angiotensin-II) elicited an antagonistic blood pressure response resembling Bartter's syndrome.

摘要

5例慢性肺部疾病患者(3例肺气肿、1例陈旧性肺结核所致慢性呼吸衰竭、1例弥漫性泛细支气管炎)血浆血管紧张素I和肾素活性水平显著升高,同时血管紧张素II水平也升高,但其体循环血压未升高。静脉输注血管紧张素II类似物(1-肌氨酸,8-异亮氨酸-血管紧张素II)引起了类似巴特综合征的拮抗血压反应。

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