苯妥英钠致小儿舞蹈症：苯妥英钠、苯巴比妥和氯巴占之间的相互作用。
Phenytoin induced chorea in a pediatric patient: An interaction between phenytoin, phenobarbital and clobazam.
机构信息
Department of Pharmacology, Government Medical College, Bhavnagar- 364 001, Gujarat, India.
出版信息
Indian J Pharmacol. 2011 Nov;43(6):731-2. doi: 10.4103/0253-7613.89839.
Abstract
A 3-year-old female patient developed chorea possibly due to an interaction between phenytoin, phenobarbital and clobazam used for generalized tonic clonic seizures. Phenytoin withdrawal resulted in recovery within 24 hours. Post reaction computerized tomography (CT)-scan of brain was normal. Combined use of anti-seizure drugs and interactions between them may be responsible for the reaction. Therapeutic drug monitoring is important while prescribing two or more anti-seizure drugs.
摘要
一位 3 岁女性患者出现舞蹈症，可能是由于苯妥英钠、苯巴比妥和氯巴占用于全身性强直阵挛发作的相互作用。停用苯妥英钠后，24 小时内恢复。脑 CT 扫描无异常。抗癫痫药物的联合使用和它们之间的相互作用可能是导致这种反应的原因。当同时开两种或更多种抗癫痫药物时，治疗药物监测很重要。
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本文引用的文献
1
Chorea associated with gabapentin use in an elderly man.
Am J Geriatr Pharmacother. 2009 Aug;7(4):220-4. doi: 10.1016/j.amjopharm.2009.08.001.
2
Phenytoin poisoning.
Neurocrit Care. 2005;3(2):161-70. doi: 10.1385/NCC:3:2:161.
3
Lamotrigine, carbamazepine and phenytoin differentially alter extracellular levels of 5-hydroxytryptamine, dopamine and amino acids.
Epilepsy Res. 2005 Feb;63(2-3):141-9. doi: 10.1016/j.eplepsyres.2005.02.002.
4
Anticonvulsants-induced chorea: a role for pharmacodynamic drug interaction?
Seizure. 2001 Dec;10(8):596-9. doi: 10.1053/seiz.2001.0555.
5
Focusing on the preventability of adverse drug reactions.
Hosp Pharm. 1992 Jun;27(6):538.
6
Phenytoin induced dyskinesia.
Indian Pediatr. 1998 Mar;35(3):274-6.
7
Possible interaction between acyclovir and antiepileptic treatment.
Ther Drug Monit. 1995 Jun;17(3):312-5.
8
A method for estimating the probability of adverse drug reactions.
Clin Pharmacol Ther. 1981 Aug;30(2):239-45. doi: 10.1038/clpt.1981.154.
9
Phenytoin toxicity due to interaction with clobazam.
Neurology. 1991 Feb;41(2 ( Pt 1)):313-4. doi: 10.1212/wnl.41.2_part_1.313.
10
Preventability and severity assessment in reporting adverse drug reactions.
Am J Hosp Pharm. 1992 Sep;49(9):2229-32.
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