Hill Emily E, Eisenmann Joey C, Gentile Douglas, Holmes Megan E, Walsh David
Department of Kinesiology, Michigan State University, East Lansing, MI, USA.
J Pediatr Endocrinol Metab. 2011;24(9-10):709-13. doi: 10.1515/jpem.2011.267.
To examine the associations between morning cortisol and adiposity in children at baseline and 9-month follow-up.
Participants included 649 (301 males, 348 females) children (9.6 +/- 0.9 years) for the cross-sectional analysis and 316 (153 males, 163 females) for the longitudinal analysis. Body mass index (BMI, kg/m2) was calculated from measured height and weight and waist circumference (WC, cm) was measured at the superior border of the iliac crest. Cortisol was assessed via saliva samples collected on a single morning. Cross-sectional and longitudinal analyses were conducted to examine the relationships between cortisol and adiposity.
Approximately 31% were overweight (17.7%) or obese (12.8%). The mean cortisol level was 9.36 +/- 5.64 nmol/L (0.34 +/- 0.20 microg/dL). At baseline, no significant correlations were found between cortisol and BMI or WC (r < 0.07). Baseline cortisol did not correlate with change in BMI z-score (r = -0.03) or WC (r < -0.01) over the follow-up period. When examined by weight status, baseline cortisol was significantly related to changes in WC (r = 0.32) and BMI z-score (r = 0.28) among overweight subjects.
A positive relationship was found between morning cortisol and change in WC over 9 months in overweight children. Future studies should examine the association between 24-h cortisol patterns and direct measures of trunk fat.
在基线期和9个月随访期研究儿童晨皮质醇与肥胖之间的关联。
横断面分析纳入649名儿童（301名男性，348名女性）（9.6±0.9岁），纵向分析纳入316名儿童（153名男性，163名女性）。根据测量的身高和体重计算体重指数（BMI，kg/m²），在髂嵴上缘测量腰围（WC，cm）。通过在一个早晨采集的唾液样本评估皮质醇。进行横断面和纵向分析以研究皮质醇与肥胖之间的关系。
约31%的儿童超重（17.7%）或肥胖（12.8%）。皮质醇平均水平为9.36±5.64 nmol/L（0.34±0.20 μg/dL）。在基线期，未发现皮质醇与BMI或WC之间存在显著相关性（r<0.07）。基线皮质醇与随访期内BMI z评分的变化（r = -0.03）或WC的变化（r<-0.01）无关。按体重状况检查时，超重受试者的基线皮质醇与WC变化（r = 0.32）和BMI z评分变化（r = 0.28）显著相关。
超重儿童中，晨皮质醇与9个月内WC变化之间存在正相关关系。未来研究应探讨24小时皮质醇模式与躯干脂肪直接测量指标之间的关联。
