Huang Lei, Obenaus Andre
Department of Biophysics & Bioengineering, Loma Linda University, Griggs Hall, Room 227, 11065 Campus St,, Loma Linda, California, 92354, USA.
Med Gas Res. 2011 Sep 6;1(1):21. doi: 10.1186/2045-9912-1-21.
Traumatic brain injury (TBI) is a major public health issue. The complexity of TBI has precluded the use of effective therapies. Hyperbaric oxygen therapy (HBOT) has been shown to be neuroprotective in multiple neurological disorders, but its efficacy in the management of TBI remains controversial. This review focuses on HBOT applications within the context of experimental and clinical TBI. We also discuss its potential neuroprotective mechanisms. Early or delayed multiple sessions of low atmospheric pressure HBOT can reduce intracranial pressure, improve mortality, as well as promote neurobehavioral recovery. The complimentary, synergistic actions of HBOT include improved tissue oxygenation and cellular metabolism, anti-apoptotic, and anti-inflammatory mechanisms. Thus HBOT may serve as a promising neuroprotective strategy that when combined with other therapeutic targets for TBI patients which could improve long-term outcomes.
创伤性脑损伤(TBI)是一个重大的公共卫生问题。TBI的复杂性使得有效治疗方法难以应用。高压氧治疗(HBOT)已被证明在多种神经系统疾病中具有神经保护作用,但其在TBI治疗中的疗效仍存在争议。本综述着重于HBOT在实验性和临床TBI背景下的应用。我们还讨论了其潜在的神经保护机制。早期或延迟进行多次低气压HBOT可降低颅内压、提高生存率,并促进神经行为恢复。HBOT的互补、协同作用包括改善组织氧合和细胞代谢、抗凋亡及抗炎机制。因此,HBOT可能是一种有前景的神经保护策略,与TBI患者的其他治疗靶点联合使用时,有望改善长期预后。