Department of Cardiology, Suleyman Demirel University, Isparta, Turkey.
Clin Appl Thromb Hemost. 2012 Jul;18(4):387-92. doi: 10.1177/1076029611427441. Epub 2011 Dec 5.
The aim of this study was to investigate the prognostic role of mean platelet volume (MPV) in patients with coronary artery ectasia (CAE). The baseline MPV values of 258 patients with CAE were screened. The mean time of follow-up was 49 ± 21 months for major adverse cardiac events (MACEs) defined as the combination of cardiac death, nonfatal myocardial infarction (MI), rehospitalization due to cardiac disorders, and readmission due to chest pain. During follow-up period, 63 (24%) MACEs developed. There were 4 (2%) cardiovascular deaths, 0 nonfatal MI, 14 (5%) rehospitalization, and 45 (17%) readmission. Mean platelet volume values were significantly higher in patients with CAE with MACEs than in patients with CAE without MACEs (9.5 ± 1.2 fL vs 8.9 ± 1.1 fL, respectively, P = .002). The rate of MACE was higher in CAE patients with MPV of >9 fL than those with MVP of ≤9 fL (33% vs. 15%, P = .001). Mean platelet volume has a prognostic value for MACEs in patients with CAE.
本研究旨在探讨平均血小板体积（MPV）在冠状动脉扩张症（CAE）患者中的预后作用。筛选了 258 例 CAE 患者的基线 MPV 值。主要不良心脏事件（MACE）的平均随访时间为 49±21 个月，定义为心脏死亡、非致死性心肌梗死（MI）、因心脏疾病再住院和因胸痛再入院的组合。在随访期间，发生了 63 例（24%）MACE。有 4 例（2%）心血管死亡，0 例非致死性 MI，14 例（5%）再住院，45 例（17%）再入院。发生 MACE 的 CAE 患者的 MPV 值明显高于未发生 MACE 的 CAE 患者（9.5±1.2fL 比 8.9±1.1fL，P=.002）。MPV＞9fL 的 CAE 患者的 MACE 发生率高于 MPV≤9fL 的患者（33%比 15%，P=.001）。MPV 对 CAE 患者的 MACE 具有预后价值。
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