华裔美国女性和白种女性的脊柱和髋部容积骨密度。
Volumetric bone mineral density at the spine and hip in Chinese American and White women.
机构信息
Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, PH8 West-864, New York, NY 10032, USA.
出版信息
Osteoporos Int. 2012 Oct;23(10):2499-506. doi: 10.1007/s00198-011-1855-z. Epub 2011 Dec 7.
UNLABELLED
This study evaluated racial differences in bone size and volumetric density at the spine and hip in pre- and postmenopausal Chinese American and White women. Compared with White women, Chinese American women have greater cortical volumetric bone density (vBMD) at the hip, congruent with the results at the peripheral skeleton.
INTRODUCTION
Chinese American women have lower rates of fracture than White women despite lower areal bone density. At the forearm and tibia, however, Chinese American women have higher cortical vBMD as well as greater trabecular and cortical thickness, but smaller bone area as measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) compared with White women. Since HR-pQCT data are obtained at peripheral sites, it is unclear whether these differences are relevant to the clinically important lumbar spine and hip. This study assesses racial differences in bone size and vBMD at the spine and hip in Chinese American and White women.
METHODS
QCT of the spine and hip was measured to assess racial differences in bone size, structure, and vBMD in pre- (n = 83) and postmenopausal (n = 50) Chinese American and White women. Data were adjusted for weight, height, physical activity, total calcium intake, parathyroid hormone, and 25-hydroxyvitamin D levels.
RESULTS
Among premenopausal women, lumbar spine trabecular vBMD was 5.8% greater in Chinese American versus White women (p = 0.01). At the hip, cortical vBMD was 3% greater at the femoral neck (p = 0.05) and 3.6% greater at the total hip (p = 0.01) in premenopausal Chinese American compared with White women. Among postmenopausal women, there was no difference in lumbar spine trabecular vBMD. Cortical vBMD was 4% greater at the total hip (p = 0.02) and tended to be greater at the femoral neck (p = 0.058) in Chinese American versus White women.
CONCLUSIONS
Consistent with earlier findings in the peripheral skeleton, cortical vBMD is greater at the hip in Chinese American versus White women.
本研究评估了中美两国绝经前和绝经后女性在脊柱和髋部的骨大小和体积密度的种族差异。与白人女性相比，华裔美国女性的髋部皮质体积骨密度（vBMD）更高，这与外周骨骼的结果一致。
引言
尽管华裔美国女性的骨密度较低，但她们的骨折率却低于白人女性。然而，在手前臂和胫骨处，与白人女性相比，华裔美国女性的皮质 vBMD 更高，骨小梁和皮质厚度更大，但骨面积更小，这是通过高分辨率外周定量计算机断层扫描（HR-pQCT）测量得出的。由于 HR-pQCT 数据是在外周部位获得的，因此尚不清楚这些差异与临床上重要的腰椎和髋部是否相关。本研究评估了中美两国绝经前和绝经后女性在脊柱和髋部的骨大小和 vBMD 的种族差异。
方法
对脊柱和髋部进行 QCT 测量，以评估绝经前（n=83）和绝经后（n=50）中美裔和白人女性在骨大小、结构和 vBMD 方面的种族差异。数据根据体重、身高、体力活动、总钙摄入量、甲状旁腺激素和 25-羟维生素 D 水平进行调整。
结果
在绝经前女性中，华裔女性的腰椎小梁 vBMD 比白人女性高 5.8%（p=0.01）。在髋部，绝经前华裔女性的股骨颈皮质 vBMD 比白人女性高 3%（p=0.05），总髋部皮质 vBMD 高 3.6%（p=0.01）。在绝经后女性中，腰椎小梁 vBMD 无差异。与白人女性相比，华裔女性的总髋部皮质 vBMD 高 4%（p=0.02），股骨颈皮质 vBMD 也有升高趋势（p=0.058）。
结论
与外周骨骼的早期发现一致，华裔美国女性的髋部皮质 vBMD 高于白人女性。
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