Department of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea.
Macromol Biosci. 2012 Feb;12(2):211-7. doi: 10.1002/mabi.201100235. Epub 2011 Dec 6.
In an attempting to find new biomaterials for mammalian cell culture, PHEMA derivatives with ester side groups are synthesized by one-step polymer-analogous reaction. These polymers show excellent antifouling properties against S. epidermidis and P. aeruginosa while their cytotoxicity and proliferation activity for HDF cell are on a similar level as commercially available TCPS. The interesting bioadhesion property is systematically correlated with surface properties of the PHEMA derivatives.
在尝试为哺乳动物细胞培养寻找新型生物材料的过程中，通过一步法聚合物类似反应合成了具有酯侧基的 PHEMA 衍生物。这些聚合物对表皮葡萄球菌和铜绿假单胞菌表现出优异的抗污性能，而其对 HDF 细胞的细胞毒性和增殖活性与市售的 TCPS 相当。有趣的生物粘附性能与 PHEMA 衍生物的表面性能有系统的相关性。
