Witkowski F X, Penkoske P A
Department of Internal Medicine, University of Alberta School of Medicine, Edmonton, Canada.
J Surg Res. 1990 Oct;49(4):337-40. doi: 10.1016/0022-4804(90)90033-x.
Many physiological investigations of cardiac function require accurate control of heart rate. To examine heart rate effects at values lower than the intrinsic heart rate requires the ability to prevent an accelerated junctional rhythm from becoming dominant even after the sinus node is eliminated. A new method for the simple and reliable production of complete atrioventricular heart block in open-chest dogs is presented. It consists of two bonded parallel 22-gauge needles, one containing a bipolar recording electrode for localization at its tip and the other used for immediately adjacent formalin injection. The catheter is easily constructed, sterilizable, reusable, and durable, and can also provide a stable means of recording the His bundle electrical activity. Initial experiments performed in the first five dogs using this technique produced complete heart block with a stable ventricular escape rhythm in all five cases.
许多关于心脏功能的生理学研究都需要精确控制心率。要研究低于固有心率时的心率效应，就需要具备即使在窦房结被消除后仍能防止加速性交界性心律成为主导的能力。本文介绍了一种在开胸犬中简单可靠地产生完全性房室传导阻滞的新方法。它由两根粘结在一起的平行22号针组成，一根在其尖端含有用于定位的双极记录电极，另一根用于紧邻部位的福尔马林注射。该导管易于制作、可消毒、可重复使用且耐用，还能提供一种稳定的记录希氏束电活动的方法。使用该技术对前五只犬进行的初始实验在所有五只犬中均产生了完全性心脏传导阻滞，并伴有稳定的心室逸搏心律。
