Department of Pathology, Hematopathology Section and Lymph Node Registry, University of Kiel, Kiel, Germany.
Pediatr Blood Cancer. 2012 Oct;59(4):732-5. doi: 10.1002/pbc.24005. Epub 2011 Dec 6.
The V600E mutation of the BRAF gene has been reported to be associated with poor prognosis of germ cell tumors in adult patients. We analyzed the mutational status of the BRAF and KRAS gene as well as MLH1 and MSH6 expression as surrogate markers for microsatellite instability in 70 pediatric germ cell tumors. Neither BRAF and KRAS mutations nor loss of MLH1 and MSH6 expression were found. Our data provide further evidence for patient age related biological differences in germ cell tumors and demonstrate that prognostic biomarkers cannot necessarily be transferred from one age group to the other.
BRAF 基因 V600E 突变已被报道与成人患者生殖细胞瘤的不良预后相关。我们分析了 70 例儿童生殖细胞瘤中 BRAF 和 KRAS 基因突变以及 MLH1 和 MSH6 表达缺失作为微卫星不稳定的替代标志物。未发现 BRAF 和 KRAS 基因突变以及 MLH1 和 MSH6 表达缺失。我们的数据进一步证明了生殖细胞瘤中与患者年龄相关的生物学差异，并表明预后生物标志物不一定可以从一个年龄组转移到另一个年龄组。
