Konishi Seiki
Department of Physiology, The University of Tokyo School of Medicine, Tokyo, Japan.
Brain Nerve. 2011 Dec;63(12):1346-51.
Neuropsychological studies using traditional tasks of inhibitory functions, such as the Wisconsin card sorting test (WCST) and the Go/No-Go Task have revealed that the frontal lobe is responsible for several types of inhibitory functions. However, the detailed psychological nature of the inhibitory functions and the precise location of their critical foci within the frontal lobe remain to be investigated. Functional magnetic resonance imaging provides spatial and temporal resolution that allowed us to illuminate at least 4 frontal regions involved in inhibitory functions: the dorsolateral, ventrolateral, and rostral parts of the frontal lobe and the presupplementary motor area (preSMA). The ventrolateral part of the frontal lobe in the right hemisphere was activated during response inhibition. The preSMA in the left hemisphere was activated during inhibition of proactive interference immediately after the dimension changes of the WCST. The rostral part of the frontal lobe in the left hemisphere was activated during inhibition long after the dimension changes. The dorsolateral part of the frontal lobe in the left hemisphere was activated at the dimension changes in the first time, but not in the second time. These findings provide clues to our understanding of functional differentiation of inhibitory functions and their localization in the frontal lobe.
使用传统抑制功能任务（如威斯康星卡片分类测验（WCST）和停止信号任务）的神经心理学研究表明，额叶负责多种类型的抑制功能。然而，抑制功能的详细心理本质及其在额叶内关键焦点的确切位置仍有待研究。功能磁共振成像提供了空间和时间分辨率，使我们能够阐明至少4个与抑制功能有关的额叶区域：额叶的背外侧、腹外侧和喙部以及辅助运动前区（preSMA）。在反应抑制期间，右半球额叶的腹外侧部分被激活。在WCST维度变化后立即抑制主动干扰期间，左半球的辅助运动前区被激活。在维度变化很久之后的抑制期间，左半球额叶的喙部被激活。左半球额叶的背外侧部分在第一次维度变化时被激活，但在第二次时未被激活。这些发现为我们理解抑制功能的功能分化及其在额叶中的定位提供了线索。
