血管紧张素II信号传导的新关键介质p63RhoGEF在人类血压调节和心血管重塑中起作用吗？ - Suppr | 超能文献

Does p63RhoGEF, a new key mediator of angiotensin II signalling, play a role in blood pressure regulation and cardiovascular remodelling in humans?

作者信息

Calò Lorenzo A, Davis Paul A, Pessina Achille C

出版信息

J Renin Angiotensin Aldosterone Syst. 2011 Dec;12(4):634-6. doi: 10.1177/1470320311407232.

DOI:10.1177/1470320311407232

Abstract

摘要

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1

Does p63RhoGEF, a new key mediator of angiotensin II signalling, play a role in blood pressure regulation and cardiovascular remodelling in humans?血管紧张素II信号传导的新关键介质p63RhoGEF在人类血压调节和心血管重塑中起作用吗？

J Renin Angiotensin Aldosterone Syst. 2011 Dec;12(4):634-6. doi: 10.1177/1470320311407232.

2

Increased level of p63RhoGEF and RhoA/Rho kinase activity in hypertensive patients.高血压患者中 p63RhoGEF 和 RhoA/Rho 激酶活性的增加。

J Hypertens. 2014 Feb;32(2):331-8. doi: 10.1097/HJH.0000000000000075.

3

The blocking of angiotensin II type 1 receptor and RhoA/Rho kinase activity in hypertensive patients: Effect of olmesartan medoxomil and implication with cardiovascular-renal remodeling.血管紧张素II 1型受体阻断及RhoA/Rho激酶活性抑制在高血压患者中的作用：奥美沙坦酯的效应及其与心血管-肾脏重塑的关系

J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):1245-50. doi: 10.1177/1470320315594324. Epub 2015 Aug 3.

4

p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts.p63RhoGEF调节心脏成纤维细胞中的自分泌和旁分泌信号传导。

J Mol Cell Cardiol. 2015 Nov;88:39-54. doi: 10.1016/j.yjmcc.2015.09.009. Epub 2015 Sep 21.

5

Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere.人p63RhoGEF是一种新型的RhoA特异性鸟嘌呤核苷酸交换因子，定位于心肌肌节。

J Cell Sci. 2002 Feb 1;115(Pt 3):629-40. doi: 10.1242/jcs.115.3.629.

6

The RhoA-specific guanine nucleotide exchange factor p63RhoGEF binds to activated Galpha(16) and inhibits the canonical phospholipase Cbeta pathway.RhoA特异性鸟嘌呤核苷酸交换因子p63RhoGEF与活化的Gα(16)结合，并抑制经典的磷脂酶Cβ途径。

Cell Signal. 2009 Aug;21(8):1317-25. doi: 10.1016/j.cellsig.2009.03.017. Epub 2009 Apr 5.

7

Gαq/p63RhoGEF interaction in RhoA/Rho kinase signaling: investigation in Gitelman's syndrome and implications with hypertension.Gαq/p63RhoGEF 相互作用在 RhoA/Rho 激酶信号通路中的研究：在 Gitelman 综合征中的研究及其与高血压的关系。

J Endocrinol Invest. 2018 Mar;41(3):351-356. doi: 10.1007/s40618-017-0749-0. Epub 2017 Aug 24.

8

Angiotensin II up-regulates the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF), a regulator of G protein signaling domain-containing RhoGEF, in vascular smooth muscle cells.血管紧张素II上调血管平滑肌细胞中白血病相关的Rho鸟嘌呤核苷酸交换因子（RhoGEF），即含G蛋白信号结构域的RhoGEF的一种调节因子。

Mol Pharmacol. 2006 Mar;69(3):932-40. doi: 10.1124/mol.105.017830. Epub 2005 Dec 14.

9

Angiotensin II type-1 receptor regulates RhoA and Rho-kinase/ROCK activation via multiple mechanisms. Focus on "Angiotensin II induces RhoA activation through SHP2-dependent dephosphorylation of the RhoGAP p190A in vascular smooth muscle cells".血管紧张素II 1型受体通过多种机制调节RhoA和Rho激酶/ROCK的激活。聚焦于“血管紧张素II通过依赖SHP2的血管平滑肌细胞中RhoGAP p190A去磷酸化诱导RhoA激活”。

Am J Physiol Cell Physiol. 2009 Nov;297(5):C1059-61. doi: 10.1152/ajpcell.00399.2009. Epub 2009 Sep 9.

10

Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.Gαq-p63RhoGEF-RhoA复合物的结构揭示了G蛋白偶联受体激活RhoA的一条途径。

Science. 2007 Dec 21;318(5858):1923-7. doi: 10.1126/science.1147554.

引用本文的文献

1

Kinetics of recruitment and allosteric activation of ARHGEF25 isoforms by the heterotrimeric G-protein Gαq.异三聚体 G 蛋白 Gαq 对 ARHGEF25 异构体的募集和变构激活的动力学。

Sci Rep. 2016 Nov 11;6:36825. doi: 10.1038/srep36825.

2

Overexpression of GEFT, a Rho family guanine nucleotide exchange factor, predicts poor prognosis in patients with rhabdomyosarcoma.Rho家族鸟嘌呤核苷酸交换因子GEFT的过表达预示着横纹肌肉瘤患者的预后不良。

Int J Clin Exp Pathol. 2014 Mar 15;7(4):1606-15. eCollection 2014.

3

p63RhoGEF: a new switch for G(q)-mediated activation of smooth muscle.p63RhoGEF：G(q)介导的平滑肌激活的新开关。

Trends Cardiovasc Med. 2012 Jul;22(5):122-7. doi: 10.1016/j.tcm.2012.07.007. Epub 2012 Aug 16.