Watanabe Y, Shimizu J, Hashizume Y, Tsunamura Y, Yamada T, Iwa T, Sakai S, Murayama T, Koshimura S, Saito M
Department of Surgery, Kanazawa University School of Medicine, Japan.
J Surg Oncol. 1990 Oct;45(2):103-9. doi: 10.1002/jso.2930450209.
We performed a prospective study on the correlation of various parameters of the immune response with the 5-year survival rate in patients with bronchogenic carcinoma. Parameters were initially examined before starting treatment. Delayed hypersensitivity skin tests, lymphoblastogenesis, natural killer (NK) cell activity, and interleukin-2 (IL-2) production were employed to assess immune competence. Each reaction was classified into four or five grades in accordance with intensity; the 5-year survival rate of the patients showing each grade of the immune response was calculated. A correlation between response before treatment and the survival rate was most clearly noted for lymphoblastogenesis. The skin tests and the NK cell activity showed poorer correlations, and no exact correlation was noted between the IL-2 production and the immune response.
我们对支气管源性癌患者免疫反应的各种参数与5年生存率之间的相关性进行了一项前瞻性研究。在开始治疗前最初对各项参数进行了检查。采用迟发型超敏皮肤试验、淋巴细胞生成、自然杀伤（NK）细胞活性和白细胞介素-2（IL-2）生成来评估免疫能力。每种反应根据强度分为四或五个等级；计算了表现出每种免疫反应等级的患者的5年生存率。对于淋巴细胞生成，治疗前反应与生存率之间的相关性最为明显。皮肤试验和NK细胞活性显示出较差的相关性，并且在IL-2生成与免疫反应之间未发现确切相关性。
