Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.
J Korean Med Sci. 2011 Dec;26(12):1541-7. doi: 10.3346/jkms.2011.26.12.1541. Epub 2011 Nov 29.
The purpose of this study was to investigate the association between body mass index (BMI) and the prevalence of wheeze using nation-wide cross-sectional study in Korean children. Total 50,200 children from 427 elementary schools were randomly selected according to residential areas (metropolitan, provincial, rural, and industrial areas) by the cluster sampling method. The International Study of Asthma and Allergies in Childhood (ISAAC) questionnaires were used to measure the prevalence of wheeze. Among 31,026 respondents, 25,322 were analyzed. BMI was classified into quartiles based on BMI-for-age percentile. In all residential areas, pets at home and visible mold or moisture were associated with an increased prevalence of wheeze in both genders. However, other living environment factors were not consistently associated among residential areas and gender. Among girls, lowest BMI was negatively associated with prevalence of wheeze and highest BMI was positively associated in all residential areas. In multilevel logistic regression analysis, environmental tobacco smoking exposure, pets at home, visible mold or moisture, and being in the lowest and highest BMI quartile were significantly associated with the prevalence of wheeze in both genders. BMI has become an important risk factor for asthma symptoms among Korean children.
本研究旨在通过全国性横断面研究调查儿童体重指数（BMI）与喘息患病率之间的关系。采用整群抽样法，根据居住地区（城市、省、农村和工业区）从 427 所小学中随机抽取了 50200 名儿童。采用儿童哮喘和过敏国际研究（ISAAC）问卷来衡量喘息的患病率。在 31026 名应答者中，分析了 25322 名应答者。根据 BMI 年龄百分位数将 BMI 分为四分位数。在所有居住地区，家中有宠物以及可见霉菌或潮湿都与男女喘息患病率的增加有关。然而，其他居住环境因素在居住地区和性别之间并不始终相关。对于女孩，最低 BMI 与喘息患病率呈负相关，而在所有居住地区，最高 BMI 与喘息患病率呈正相关。在多层次逻辑回归分析中，环境烟草暴露、家中有宠物、可见霉菌或潮湿以及处于最低和最高 BMI 四分位数与男女喘息患病率显著相关。BMI 已成为韩国儿童哮喘症状的一个重要危险因素。
