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白喉毒素酶活性片段A的氨基酸序列。I. 马来酰化蛋白的胰蛋白酶肽段

The amino acid sequence of fragment A, an enzymically active fragment of diphtheria toxin. I. The tryptic peptides from the maleylated protein.

作者信息

DeLange R J, Williams L C, Collier R J

出版信息

J Biol Chem. 1979 Jul 10;254(13):5827-31.

PMID:221482
Abstract

Six tryptic peptides ranging in size from 3 to 126 residues were isolated from maleylated Fragment A of diphtheria toxin after tryptic hydrolysis. These peptides accounted for all 193 residues found by amino acid analysis. After demaleylation, the six peptides were purified by chromatography on Sephadex G-50, coupled with paper chromatography and electrophoresis, and were analyzed by various methods. The compositions and properties of the peptides are reported. Almost 70% of the residues were positioned within these peptides.

摘要

经胰蛋白酶水解后，从白喉毒素的马来酰化A片段中分离出6条大小从3至126个残基不等的胰蛋白酶肽段。这些肽段涵盖了氨基酸分析所发现的全部193个残基。脱马来酰化后，这6条肽段通过Sephadex G - 50柱色谱进行纯化，并结合纸色谱和电泳法，然后采用各种方法进行分析。报告了这些肽段的组成和性质。几乎70%的残基位于这些肽段中。

相似文献

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The amino acid sequence of fragment A, an enzymically active fragment of diphtheria toxin. I. The tryptic peptides from the maleylated protein.白喉毒素酶活性片段A的氨基酸序列。I. 马来酰化蛋白的胰蛋白酶肽段
J Biol Chem. 1979 Jul 10;254(13):5827-31.
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引用本文的文献

1
Tryptic peptide analysis of outer capsid polypeptides of mammalian reovirus serotypes 1, 2, and 3.哺乳动物呼肠孤病毒1、2和3型外衣壳多肽的胰蛋白酶肽分析
J Virol. 1981 Apr;38(1):208-18. doi: 10.1128/JVI.38.1.208-218.1981.
2
Nucleotide sequence of the structural gene for diphtheria toxin carried by corynebacteriophage beta.由β棒状噬菌体携带的白喉毒素结构基因的核苷酸序列。
Proc Natl Acad Sci U S A. 1983 Nov;80(22):6853-7. doi: 10.1073/pnas.80.22.6853.