Witte M H, Witte C L, Way D L, Fiala M
Department of Surgery, University of Arizona College of Medicine, Tucson.
Lymphology. 1990 Jun;23(2):73-80.
Based on ongoing basic and clinical investigations, further evidence is presented that the AIDS-Kaposi sarcoma (AIDS-KS) complex involves a progressive disturbance of the blood-lymph circulatory loop of fluid, macromolecules, and migrating cells. We first surveyed the spectrum of vascular abnormalities including Kaposi sarcoma (KS) found in the AIDS/ARC population, then non-invasively imaged lymphatic system abnormalities in AIDS-KS by whole body lymphangioscintigraphy, and finally examined the biologic behavior of AIDS-KS cells in long-term tissue culture. These observations are viewed in terms of the lymphatic and blood vascular route of entry and transport of free and cell-associated virus and other opportunistic pathogens as well as poorly understood host endothelial-immune system interactions.
基于正在进行的基础和临床研究，进一步的证据表明，艾滋病-卡波西肉瘤（AIDS-KS）综合征涉及液体、大分子和迁移细胞的血液-淋巴循环回路的进行性紊乱。我们首先调查了艾滋病/艾滋病相关综合征（ARC）人群中发现的包括卡波西肉瘤（KS）在内的血管异常谱，然后通过全身淋巴管闪烁造影对AIDS-KS患者的淋巴系统异常进行无创成像，最后在长期组织培养中研究AIDS-KS细胞的生物学行为。从游离和细胞相关病毒及其他机会性病原体进入和运输的淋巴和血管途径以及了解甚少的宿主内皮-免疫系统相互作用的角度来看待这些观察结果。
