Torrès H, Dubreuil P, Falzetti F, Courcoul M A, Lopez M, Falcinelli F, Birg F, Tabilio A, Mannoni P
Unité 119 de l'INSERM, Institut Paoli-Calmettes, Marseille, France.
Leukemia. 1990 Oct;4(10):673-7.
The c-fms proto-oncogene product, which is the receptor for the macrophage colony-stimulating factor CSF-1, is always found expressed in acute myeloid leukemia cells, irrespective of their stage of differentiation according to the FAB classification (Dubreuil P, Torrès H, Courcoul M, Birg F, Mannoni P. Blood 1988;72:1081-1085). We have extended this study and looked for c-fms expression in poorly differentiated myeloid leukemias, in a series of acute leukemias of either T or B origin and in biphenotypic leukemias. We now report that expression of c-fms is still related to the myeloid origin of the leukemic proliferation, but that it can also be found in some acute leukemias presenting clonal rearrangements of the T cell receptor gene. Thus expression of the c-fms/CSF-1 receptor may not be exclusively a marker for myeloid proliferations.
c-fms原癌基因产物是巨噬细胞集落刺激因子CSF-1的受体，在急性髓性白血病细胞中总是呈表达状态，无论根据FAB分类其处于何种分化阶段（Dubreuil P，Torrès H，Courcoul M，Birg F，Mannoni P。《血液》1988年；72：1081 - 1085）。我们扩展了这项研究，在低分化髓性白血病、一系列T或B起源的急性白血病以及双表型白血病中寻找c-fms的表达。我们现在报告，c-fms的表达仍然与白血病增殖的髓系起源相关，但在一些出现T细胞受体基因克隆重排的急性白血病中也能发现。因此，c-fms/CSF-1受体的表达可能并非仅仅是髓系增殖的标志物。
