Expert Opin Emerg Drugs. 2011 Dec;16(4):603-6. doi: 10.1517/14728214.2011.644273. Epub 2011 Dec 8.
One in ten adults has clinically significant subjective tinnitus, and for one in hundred, tinnitus severely affects their quality of life. Despite the significant unmet clinical need for a safe and effective drug targeting tinnitus relief, there is currently not a single FDA-approved drug on the market. Even a drug that produces a small but significant effect would have a huge therapeutic impact. In the last few years, there have been significant advances in i) the understanding of the pathophysiology of the different forms of tinnitus, ii) the establishment of valid animal models and iii) the development of clinical trial methodology. A glimpse of hope is appearing in the horizon as an increasing number of pharmaceutical industries now have compounds targeting tinnitus in their pipeline.
十分之一的成年人存在具有临床意义的主观性耳鸣，百分之一的人耳鸣严重影响其生活质量。尽管安全有效的药物治疗耳鸣缓解存在巨大的临床需求，但目前市场上尚无一种获得 FDA 批准的药物。即使是一种能产生微小但显著效果的药物，也将具有巨大的治疗效果。在过去几年中，人们在以下方面取得了重大进展：i）不同类型耳鸣的病理生理学的理解，ii）有效动物模型的建立，以及 iii）临床试验方法的发展。随着越来越多的制药公司在其研发管线中加入针对耳鸣的化合物，一线希望正在出现。
