通过无创成像视角理解冠状动脉疾病的遗传学。
Understanding the genetics of coronary artery disease through the lens of noninvasive imaging.
作者信息
Yang Eunice, Vargas Jose D, Bluemke David A
机构信息
Johns Hopkins School of Medicine, Baltimore, MD, USA.
出版信息
Expert Rev Cardiovasc Ther. 2012 Jan;10(1):27-36. doi: 10.1586/erc.11.175.
Coronary artery disease is a common condition with a known heritable component that has spurred interest in genetic research for decades, resulting in a handful of candidate genes and an appreciation for the complexity of its genetic contributions. Recent advances in sequencing technologies have resulted in large-scale association studies, possibly adding to our current understanding of the genetics of coronary artery disease. Sifting through the statistical noise, however, requires the selection of effective phenotypic markers. New imaging technologies have improved our ability to detect subclinical atherosclerosis in a safe and reproducible manner in large numbers of patients. In this article, we propose that advances in imaging technology have generated improved phenotypic markers for genetic association studies of coronary artery disease.
冠状动脉疾病是一种常见疾病，具有已知的遗传成分，几十年来一直激发着人们对基因研究的兴趣，产生了一些候选基因，并让人们认识到其遗传贡献的复杂性。测序技术的最新进展已促成了大规模关联研究，可能会增进我们目前对冠状动脉疾病遗传学的理解。然而，要从统计噪声中筛选出有效信息，需要选择有效的表型标记。新的成像技术提高了我们以安全且可重复的方式在大量患者中检测亚临床动脉粥样硬化的能力。在本文中，我们提出成像技术的进步为冠状动脉疾病的基因关联研究产生了改进的表型标记。
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