入院降钙素原对急性冠脉综合征预后的影响：一项初步研究。
The impact of admission procalcitonin on prognosis in acute coronary syndromes: a pilot study.
机构信息
Intensive Cardiac Care Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
出版信息
Biomarkers. 2012 Feb;17(1):56-61. doi: 10.3109/1354750X.2011.638398. Epub 2011 Dec 8.
BACKGROUND
Available evidence on the prognostic role of procalcitonin levels in acute coronary syndromes (ACS) is so far controversial.
AIMS
To evaluate the association between procalcitonin, major cardiovascular events (MACE) and total mortality in acute coronary syndromes.
METHODS
Procalcitonin levels were measured in 247 patients admitted to our Intensive Cardiac Care Unit (ICCU) with ACS. Three subgroups were considered according to procalcitonin levels.
RESULTS
At Cox regression analysis, procalcitonin levels were both an unadjusted and an adjusted predictor (corrected for diagnosis and TnI) of intra-ICCU mortality and of 1-year follow-up MACE and total mortality.
CONCLUSIONS
In ACS, admission procalcitonin values identify a "higher risk" group of patients for short and long-term mortality.
背景
目前有关降钙素原水平在急性冠脉综合征（ACS）中的预后作用的证据尚存在争议。
目的
评估降钙素原与急性冠脉综合征患者的主要心血管不良事件（MACE）和总死亡率之间的相关性。
方法
对入住我院重症心脏监护病房（ICCU）的 247 例 ACS 患者进行降钙素原水平检测。根据降钙素原水平将患者分为三组。
结果
在 Cox 回归分析中，降钙素原水平是 ICU 内死亡率和 1 年随访期间 MACE 和总死亡率的未经调整和校正预测因子（校正诊断和 TnI）。
结论
在 ACS 中，入院时降钙素原值可识别短期和长期死亡率较高的“高危”患者群体。
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