因在同侧前臂皮肤上使用雌二醇喷雾而导致的乳头和乳晕色素沉着过度：两例报告。
Nipple and areolar hyperpigmentation secondary to the use of estradiol spray on the ipsilateral forearm skin: a report of two cases.
机构信息
University of Texas Medical School-Houston, Houston, Texas 77030-1503, USA.
出版信息
J Womens Health (Larchmt). 2012 Mar;21(3):363-5. doi: 10.1089/jwh.2011.2959. Epub 2011 Dec 13.
BACKGROUND
Metered transdermal estradiol spray may cause ipsilateral hyperpigmentation of the nipple and areola.
CASES
Two women who were using transdermal estradiol spray for the treatment of postmenopausal symptoms developed hyperpigmentation of the ipsilateral areola and nipple. The appearance was variable in onset and did not appear to be related to the duration of use.
CONCLUSION
Estradiol transdermal spray can have the rare side effect of ipsilateral nipple and areolar hyperpigmentation. The time of onset can vary.
背景
经皮雌二醇喷雾可能会导致同侧乳头和乳晕出现色素沉着。
病例
两名正在使用经皮雌二醇喷雾治疗绝经后症状的女性出现了同侧乳晕和乳头的色素沉着。发病的表现各不相同，似乎与使用时间无关。
结论
雌二醇经皮喷雾可能会产生罕见的同侧乳头和乳晕色素沉着的副作用。发病时间可能有所不同。
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