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右半肝活体肝移植术后胆系并发症:单中心经验。

Biliary complications after right lobe living donor liver transplantation: a single-centre experience.

机构信息

Florence Nightingale Hospital, Hepatobiliary and Organ Transplant Center, Istanbul, Turkey.

出版信息

HPB (Oxford). 2012 Jan;14(1):49-53. doi: 10.1111/j.1477-2574.2011.00401.x. Epub 2011 Oct 25.

Abstract

BACKGROUND

Biliary complications that developed after right lobe liver transplantation from living donors were studied in a single centre.

METHODS

From 2004 to 2010, 200 consecutive living donor right lobe liver transplantations were performed. The database was evaluated retrospectively. Biliary complications were diagnosed according to clinical, biochemical and radiological tests. The number of biliary ducts in the transplanted graft, the surgical techniques used for anastomosis, biliary strictures and bile leakage rates were analysed.

RESULTS

Of a total of 200 grafts, 117 invloved a single bile duct, 77 had two bile ducts and in six grafts there were three bile ducts. In 166 transplants, the anastomosis was performed as a single duct to duct, in 21 transplants double duct to ducts, in one transplant, three duct to ducts and in 12 transplants as a Roux-en-Y reconstruction. In all, 40 bile leakages (20%) and 17 biliary strictures (8.5%) were observed in 49 patients resulting in a total of 57 biliary complications (28.5%). Seventeen patients were re-operated (12 as a result of bile leakages and five owing to biliary strictures).

CONCLUSION

Identification of more than one biliary orifice in the graft resulted in an increase in the complication rates. In grafts containing multiple orifices, performing multiple duct-to-duct (DD) or Roux-en-Y anastomoses led to a lower number of complications.

摘要

背景

在一个中心研究了活体供者右叶肝移植后发生的胆道并发症。

方法

2004 年至 2010 年,进行了 200 例连续的活体供者右叶肝移植。回顾性评估数据库。根据临床、生化和影像学检查诊断胆道并发症。分析移植肝中胆管的数量、用于吻合的手术技术、胆管狭窄和胆漏的发生率。

结果

在总共 200 个移植物中,117 个涉及单个胆管,77 个有两个胆管,6 个有三个胆管。在 166 例移植中,吻合采用单胆管对胆管,21 例采用双胆管对胆管,1 例采用三胆管对胆管,12 例采用 Roux-en-Y 重建。共有 49 例患者发生 40 例胆漏(20%)和 17 例胆管狭窄(8.5%),导致 57 例胆道并发症(28.5%)。共有 17 例患者再次手术(12 例因胆漏,5 例因胆管狭窄)。

结论

在供肝中发现一个以上胆管口会增加并发症的发生率。在含有多个口的供肝中,行多个胆管对胆管(DD)或 Roux-en-Y 吻合可降低并发症的发生率。

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本文引用的文献

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