Silverberg J, O'Donnell J, Sugenoya A, Row V V, Volpé R
J Clin Endocrinol Metab. 1978 Mar;46(3):420-4. doi: 10.1210/jcem-46-3-420.
Thyroid stimulating substances other than TSH have been found in certain disease states associated with hyperthyroidism. The thyroid stimulator associated with the thyrotoxicosis of trophoblastic disease is uncertain; however, recent evidence suggests a role for hCG. To explore the thyroid stimulating properties of hCG further, we examined the ability of hCG to displace [1252]TSH from receptors on human thyroid membrane and to generate cyclic-AMP (c-AMP) from human thyroid slices. Human chorionic gonadotropin at a concentration of 40 IU/ml displaced labeled TSH from human thyroid membranes and, at a concentration of 69 IU/ml, hCG caused the generation of c-AMP in thyroid slices. These results suggest that hCG can bind to the TSH receptor on thyroid cells and can stimulate them to produce c-AMP at concentrations of hCG within the range that is found in trophoblastic disease.
在某些与甲状腺功能亢进相关的疾病状态中，已发现除促甲状腺激素（TSH）外的甲状腺刺激物质。与滋养层疾病甲状腺毒症相关的甲状腺刺激物尚不确定；然而，最近的证据表明人绒毛膜促性腺激素（hCG）发挥了作用。为了进一步探究hCG的甲状腺刺激特性，我们检测了hCG从人甲状腺膜受体上置换[125I]TSH的能力以及从人甲状腺切片中生成环磷酸腺苷（c-AMP）的能力。浓度为40 IU/ml的人绒毛膜促性腺激素可从人甲状腺膜上置换标记的TSH，浓度为69 IU/ml时，hCG可导致甲状腺切片中生成c-AMP。这些结果表明，hCG可与甲状腺细胞上的TSH受体结合，并能在滋养层疾病中发现的hCG浓度范围内刺激甲状腺细胞产生c-AMP。
