Centre for Health Economics, The University of York, Heslington, York, United Kingdom.
Value Health. 2011 Dec;14(8):1135-41. doi: 10.1016/j.jval.2011.09.002. Epub 2011 Nov 6.
Cost-effectiveness analysis has been recommended by many national agencies around the world as a valid methodology to improve resource allocation within the health-care system. If the preferences of the society are taken into account in such a decision-making process, it is generally recommended that these values should be elicited by using a generic health-related quality-of-life instrument, such as the EuroQol five-dimensional (EQ-5D) questionnaire.
To estimate a set of social values for EQ-5D questionnaire based on the time trade-off valuation technique for use in Chile.
A valuation questionnaire was applied to a probabilistic sample of 2000 individuals, aged 20 years or older, living in the Metropolitan region. The fieldwork took place during October to November 2008. Utility weights for 42 health states were calculated directly by the application of time trade-off. Several random effect and ordinary least-squares regression models were fitted to these valuations to predict the full set of 243 health states generated by the EQ-5D system. The best model was chosen by applying criteria of parsimony, goodness of fit, and prediction capacity.
The selected regression model was robust and showed better predictive characteristics than others reported in similar studies conducted elsewhere. The chosen regression model showed a R(2) of 0.34, mean absolute error of 0.017, and high predictive capacity.
This study provides an EQ-5D social value set for domestic use in Chile. Our results differ from those reported in other countries, justifying the need to perform local studies that adequately reflect societal health preferences.
成本效益分析已被世界上许多国家机构推荐为一种有效的方法，用于改善医疗保健系统内的资源分配。如果在这样的决策过程中考虑到社会的偏好，通常建议使用通用的健康相关生活质量工具（如 EuroQol 五维（EQ-5D）问卷）来得出这些价值观。
为智利开发一套基于时间权衡估值技术的 EQ-5D 问卷社会价值。
对 2000 名年龄在 20 岁及以上、居住在首都地区的概率样本应用了估值问卷。实地调查于 2008 年 10 月至 11 月进行。通过时间权衡法直接计算了 42 种健康状况的效用权重。通过应用随机效应和普通最小二乘回归模型拟合这些估值，来预测 EQ-5D 系统生成的全部 243 种健康状况。通过简洁性、拟合优度和预测能力的标准来选择最佳模型。
所选回归模型具有稳健性，并且表现出比其他地方进行的类似研究报告的更好的预测特征。所选择的回归模型显示 R²为 0.34，平均绝对误差为 0.017，具有较高的预测能力。
本研究提供了智利国内使用的 EQ-5D 社会价值集。我们的结果与其他国家报告的结果不同，证明有必要进行充分反映社会健康偏好的本地研究。
