Rauh W, Levine L S, Gottesdiener K, Chow D, Oberfield S E, Gunczler P, Pareira J, New M I
J Clin Endocrinol Metab. 1979 Jul;49(1):52-7. doi: 10.1210/jcem-49-1-52.
The effect of a continuous 5-day ACTH infusion (40 U/24 h) on adrenocorticoid function, electrolyte metabolism, and blood pressure was investigated in eight normotensive children and eight patients with hypertension of unknown origin. There was a continuous rise of plasma cortisol and deoxycorticosterone in all patients. Plasma aldosterone rose transiently in the normotensive and the hypertensive group. A transient kaliuresis and a continuous fall in serum K+ were observed in all patients. ACTH induced sodium retention and weight gain. The observed increase in systolic blood pressure correlated significantly with the cumulative sodium retention in the normotensive and the hypertensive groups. No correlation between sodium retention and diastolic pressure was found. ACTH on a low salt diet (10 meq/24 h) produced a blood pressure rise which was smaller than that on regular salt. The blood pressure rise did not correlate with any of the hormones measured. This study provides evidence for an unidentified ACTH-stimulable adrenal factor capable of raising blood pressure in normotensive children and patients with juvenile hypertension. The ACTH-induced blood pressure rise is only partly salt dependent and the mechanism of the rise remains unclear.
在8名血压正常的儿童和8名不明原因高血压患者中，研究了连续5天输注促肾上腺皮质激素（ACTH，40 U/24 h）对肾上腺皮质功能、电解质代谢和血压的影响。所有患者的血浆皮质醇和脱氧皮质酮均持续升高。正常血压组和高血压组的血浆醛固酮均短暂升高。所有患者均出现短暂性尿钾增多和血清钾持续下降。ACTH导致钠潴留和体重增加。在正常血压组和高血压组中，观察到的收缩压升高与累积钠潴留显著相关。未发现钠潴留与舒张压之间存在相关性。低钠饮食（10 meq/24 h）时ACTH引起的血压升高幅度小于正常饮食时。血压升高与所测的任何一种激素均无相关性。本研究为一种未明确的、可被ACTH刺激的肾上腺因子提供了证据，该因子能够使血压正常的儿童和青少年高血压患者血压升高。ACTH引起的血压升高仅部分依赖于盐，其升高机制尚不清楚。
