Jensen Tina Kold, Skakkebæk Niels Erik, Jørgensen Niels, Blomberg Jensen Martin, Juul Anders
Klinik for Vækst og Reproduktion, Rigshospitalet, Blegdamsvej 9, 2100 København Ø, Denmark.
Ugeskr Laeger. 2011 Dec 12;173(50):3253-5.
In a Cochrane review the authors suggest that treatment with antioxidant supplementation in subfertile men may improve the outcome of live birth and pregnancy rate for infertile couples undergoing assisted reproductive technology cycles. We disagree as publication bias cannot be excluded and most studies were designed to investigate the effects of antioxidant treatment on semen quality. In addition, the men were treated with many different combinations and doses of antioxidants and it is not possible to recommend infertile men on type and dose of antioxidant. Future studies should be large, randomized placebo-controlled trials.
在一项Cochrane综述中，作者们认为，对不育男性进行抗氧化剂补充治疗可能会改善接受辅助生殖技术周期治疗的不育夫妇的活产结局和妊娠率。我们不同意这种观点，因为无法排除发表偏倚，而且大多数研究旨在调查抗氧化剂治疗对精液质量的影响。此外，男性接受了许多不同组合和剂量的抗氧化剂治疗，因此无法就抗氧化剂的类型和剂量向不育男性提供建议。未来的研究应该是大型的、随机的、安慰剂对照试验。
